1334145-40-2Relevant academic research and scientific papers
Asymmetric michael addition of malonates to enones catalyzed by a primary Β-amino acid and its lithium salt
Yoshida, Masanori,Narita, Mao,Hara, Shoji
, p. 8513 - 8517 (2011/12/03)
Highly enantioselective Michael addition of malonates to enones was achieved using a mixed catalyst consisting of a primary Β-amino acid, O-TBDPS (S)-Β-homoserine, and its lithium salt. Various cyclic and acyclic enones were converted into 1,5-ketoesters in high yields (up to 92%) with high enantioselectivity (up to 97% ee) under mild reaction conditions. Details of synthesis of the catalyst, optimization of the reaction conditions for the Michael addition reaction, and a plausible reaction mechanism are described.
