1105701-46-9Relevant academic research and scientific papers
Palladium-catalyzed cyclization/carbonylation as a direct route to 4-[(methoxycarbonyl)methyl]-3,4-dihydroisoquinolinones
Ardizzoia, G. Attilio,Beccalli, Egle M.,Borsini, Elena,Brenna, Stefano,Broggini, Gianluigi,Rigamonti, Micol
, p. 5590 - 5596 (2008)
An efficient synthetic protocol for the preparation of 4-[(methoxycarbonyl) methyl]-3,4-dihydroisoquinolin-1-ones from N-allylamides of 2-iodobenzoic acids has been performed under 100 atm of carbon monoxide. Pyridine ring formation occurs through an intramolecular Pd-catalyzed carbon-carbon bond formation, followed by an alkoxycarbonylation process. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
