110576-01-7Relevant articles and documents
Microwave assisted synthesis of S-trityl and S-acylmercaptoalkanols, nucleosides and their deprotection
Kumar,Gupta
, p. 635 - 636 (1996)
Simple and high yielding methods for the synthesis and deprotection of S-trityl and S-acylhexanols and appropriately protected 2'-deoxynucleosides in solvent and dry media conditions are described which occur under mild conditions using microwave irradiation.
ANTISENSE NUCLEIC ACID DERIVATIVE
-
, (2008/06/13)
A compound represented by general formula (1), its salt, and antiviral and antitumor drugs containing the same, wherein k is 0 to 20; m is 0 or 1; n is 4 to 29; X represents OH, methyl, sulfhydryl, C1 to C4 alkoxy or C1 to C6 monoalkylamino; Y and Z represent each O or S; R1, R2 and R3 may be the same or different from each other and each represents H, C1 to C6 alkyl, or C6 to C10 aryl which may have the substitutent(s) of group α; and D and B represent each independently a residue of any of the compounds of group β; provided that m is 0 when k is 0, and a base sequence containing B is complementary to a tumor gene or a virus gene: group α: OH, C1 to C6 alkyl, C1 to C6 alkoxy, methylenedioxy, nitro, azido, halogen, C6 to C10 aryl, C6 to C10 aryloxy, and aralkyloxy composed of a C6 to C10 aryl moiety and a C1 to C2 alkyl moiety, group β: adenine guanine, cytosine and thymine.
