110596-03-7

Upstream product

• 18325-45-6 trityl 2-hydroxyethyl ether 
• 98-59-9 p-toluenesulfonyl chloride 
• 76-83-5 trityl chloride 

Downstream Products

• 249622-00-2 (-)-(1R,2R)-2-methoxy-1-(2-trityloxyethoxy)-1,2-diphenylethane 
• 110596-08-2 (2Z)-1-hydroxy-3-methyl-6-triphenylmethyloxy-2-hexene 
• 110596-04-8 methyl 3-oxo-6-triphenylmethyloxy-hexanoate 
• 110596-09-3 (2Z)-1-benzyloxy-3-methyl-6-triphenylmethyloxy-2-hexene 
• 110596-05-9 diethyl 3-methyl (2E)-6-triphenylmethyloxy-2-hexanoatelyl phosphate 
• 110596-06-0 methyl (2Z)-3-methyl-6-triphenylmethyloxy-2-hexenoate 
• 110596-07-1 methyl (2E)-3-methyl-6-triphenylmethyloxy-2-hexenoate 

Relevant academic research and scientific papers

SYNTHESIS OF MOENOCINOL

3-Benzyloxy-2,2-dimethylpropanal (2) is converted in eight convenient steps into C18-aldehyde intermediate 10.Main steps in the synthesis of the missing C7-unit 18 were γ-alkoxyethylation of methyl acetoacetate and cis-selective meth

INHIBITORS OF CYCLIN-DEPENDENT KINASES AND USES THEREOF

Provided are novel compounds of Formula (I); pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by CDK such as cancer.

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.