1106-03-2

Basic information

• Product Name: 16-Meprednisone acetate
• Synonyms: 17,21-dihydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 21-acetate;16-meprednisone acetate;21-Acetyloxy-17-hydroxy-16β-methylpregna-1,4-diene-3,11,20-trione;[2-[(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-10,13,16-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate;[2-[(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-10,13,16-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate;acetic acid [2-[(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-3,11-diketo-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester;(16β)-21-(Acetyloxy)-17-hydroxy-16-Methyl-pregna-1,4-diene-3,11,20-trione;17,21-Dihydroxy-16β-Methyl-pregna-1,4-diene-3,11,20-trione 21-Acetate
• CAS NO: 1106-03-2
• Molecular Formula: C₂₄H₃₀O₆
• Molecular Weight: 414.4914
• EINECS: 214-167-4
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 1106-03-2.mol

Chemical Properties

• Boiling Point: 584.3 °C at 760 mmHg
• Flash Point: 198.1 °C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 4.35E-16mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 16-Meprednisone acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 16-Meprednisone acetate(1106-03-2)
• EPA Substance Registry System: 16-Meprednisone acetate(1106-03-2)

Safety Data

• Hazardous Substances Data: 1106-03-2(Hazardous Substances Data)

Usage

Uses

Anti-inflammatory Corticosteroid.

InChI:InChI=1/C24H30O6/c1-13-9-18-17-6-5-15-10-16(26)7-8-22(15,3)21(17)19(27)11-23(18,4)24(13,29)20(28)12-30-14(2)25/h7-8,10,13,17-18,21,29H,5-6,9,11-12H2,1-4H3/t13-,17-,18-,21+,22-,23-,24-/m0/s1

Upstream product

• 1253-36-7 21-acetoxy-17-hydroxy-16β-methyl-5β-pregnane-3,11,20-trione 
• 18769-24-9 16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate 

Downstream Products

• 1247-42-3 meprednisone 

Relevant articles and documents

Preparation method of methyl metacortandracin

The invention discloses a preparation method of methyl metacortandracin. The methyl metacortandracin is prepared by taking 16-b methyl-9 (11) a-epoxy-prednisolone acetate (called as DB11 for short) as a raw material; dissolving the raw material in an organic solvent and reacting with hydrobromic acid to obtain bromine hydroxyl content 9a bromine-16b methyl-prednisolone acetate; performing catalytic hydrogenation and 9-bit debromination on bromine hydroxyl content in the organic solvent by acid-binding agent and palladium carbon to obtain a debromination matter 16b methyl-metacortandracin; oxidizing the debromination matter with strong oxidant in the organic solvent to obtain prednisolone acetate; finally, hydrolyzing the prednisolone acetate in the organic solvent by catalyst to obtain methyl metacortandracin. The total weight yield through four-step synthesis is 52-55%. The production method is wide in raw material source, economic and environment-friendly in technique, short in synthesis route, and high in production yield; the production cost is 30-40% lower than that of the traditional method, and 15-20% lower than the method of application number 201610952306.6; the technique is simple and convenient; the solvent can be recycled and used indiscriminately; the preparation method is easy to practice the industrial production.