110630-87-0

Basic information

• Product Name: (4-bromo-2-chlorophenoxy)acetyl chloride
• Synonyms: (4-bromo-2-chlorophenoxy)acetyl chloride;acetyl chloride, (4-bromo-2-chlorophenoxy)-;2-(4-bromo-2-chlorophenoxy)acetyl chloride;2-(4-bromo-2-chloro-phenoxy)acetyl chloride;2-(4-bromo-2-chloro-phenoxy)ethanoyl chloride
• CAS NO: 110630-87-0
• Molecular Formula: C₈H₅BrCl₂O₂
• Molecular Weight: 283.9341
• Mol File: 110630-87-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-bromo-2-chlorophenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromo-2-chlorophenoxy)acetyl chloride(110630-87-0)
• EPA Substance Registry System: (4-bromo-2-chlorophenoxy)acetyl chloride(110630-87-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 110630-87-0(Hazardous Substances Data)

Upstream product

• 1040308-89-1 (4-bromo-2-chloro-phenoxy)-acetic acid methyl ester 
• 77228-67-2 2-(4-bromo-2-chlorophenoxy) acetic acid 
• 588679-10-1 ethyl 2-(4-bromo-2-chlorophenoxy)acetate 

Downstream Products

• 497081-40-0 2-(4'-bromo-2'-chlorophenoxy)-N-(4'-sulfamoylphenyl)acetamide 
• 587841-73-4 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide 
• 1449004-69-6 2-(4-bromo-2-chlorophenoxy)-N-(3-(N-(N-carbobenzoxy-L-leucyl)-sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-68-5 2-(4-bromo-2-chlorophenoxy)-N-(3-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-67-4 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-Lisoleucyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-66-3 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-Lleucyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-65-2 N-(4-(N-(N-carbobenzoxy-(L-leucyl))-sulfamoyl)phenylcarbamothioyl)-2-(4-bromo-2-chlorophenoxy)acetamide 
• 1449004-64-1 N-(4-(N-(L-leucyl)sulfamoyl)-phenylcarbamothioyl)-2-(4-bromo-2-chlorophenoxy) acetamide 
• 1449004-38-9 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-Ltryptophanyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-37-8 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-L-3-(4-nitrophenyl)alanyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-36-7 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-Lphenylalanyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-35-6 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-34-5 (S)-2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-2-(4-acetoxyphenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-33-4 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-2-phenylglycyl)sulfamoyl)phenylcarbamothioyl)acetamide 

Relevant articles and documents

Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors

Human African trypanosomiasis (HAT), caused by the parasitic protozoa Trypanosoma brucei, is one of the fatal diseases in tropical areas and current medicines are insufficient. Thus, development of new drugs for HAT is urgently needed. Leucyl-tRNA synthetase (LeuRS), a recently clinically validated antimicrobial target, is an attractive target for development of antitrypanosomal drugs. In this work, we report a series of α-phenoxy-N-sulfonylphenyl acetamides as T. brucei LeuRS inhibitors. The most potent compound 28g showed an IC50 of 0.70 μM which was 250-fold more potent than the starting hit compound 1. The structure-activity relationship was also discussed. These acetamides provided a new scaffold and lead compounds for the further development of clinically useful antitrypanosomal agents.

Cdc42 Inhibitor and Uses Thereof

Compounds which inhibit the small G protein Rho GTPase cell division cycle protein Cdc42 are provided. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and effects on cellular wound healing and on growth cone formation all demo