77228-67-2

Basic information

• Product Name: (4-BROMO-2-CHLOROPHENOXY)ACETIC ACID
• Synonyms: (4-bromo-2-chlorophenoxy)acetic acid(SALTDATA: FREE);2-(4-bromo-2-chloro-phenoxy)ethanoic acid
• CAS NO: 77228-67-2
• Molecular Formula: C₈H₆BrClO₃
• Molecular Weight: 265.5
• Mol File: 77228-67-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 365.1°C at 760 mmHg
• Flash Point: 174.6°C
• Appearance: /
• Vapor Pressure: 5.7E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4-BROMO-2-CHLOROPHENOXY)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMO-2-CHLOROPHENOXY)ACETIC ACID(77228-67-2)
• EPA Substance Registry System: (4-BROMO-2-CHLOROPHENOXY)ACETIC ACID(77228-67-2)

Safety Data

• Hazardous Substances Data: 77228-67-2(Hazardous Substances Data)

Usage

General Description

(4-Bromo-2-chlorophenoxy)acetic acid, also known as bromoxynil, is a synthetic herbicide that is commonly used to control broadleaf weeds in agricultural and horticultural crops. It works by interfering with plant growth hormones, specifically the auxin signaling pathway, leading to stunted growth and eventual death of the targeted weeds. Bromoxynil is highly effective against a wide range of weeds and is typically applied as a post-emergent spray. However, it is important to note that bromoxynil can be toxic to aquatic organisms and has the potential to leach into groundwater, so it should be used with caution to minimize environmental impact. Additionally, proper personal protective equipment and application techniques should be followed to prevent potential harm to humans and non-target organisms.

InChI:InChI=1/C8H6BrClO3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)/p-1

Upstream product

• 614-61-9 (2-chlorophenoxy)acetic acid 
• 3964-56-5 4-bromo-2-chlorophenol 
• 105-36-2 ethyl bromoacetate 
• 1040308-89-1 (4-bromo-2-chloro-phenoxy)-acetic acid methyl ester 
• 588679-10-1 ethyl 2-(4-bromo-2-chlorophenoxy)acetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 1107603-77-9 C₂₃H₃₁BrClNO₅ 
• 1107603-78-0 C₂₃H₃₁BrClNO₅ 
• 110630-87-0 C₈H₅BrCl₂O₂ 
• 587841-69-8 2-(4-bromo-2-chlorophenoxy)-N-(4-sulfamoylphenylcarbamothioyl)acetamide 
• 1449004-30-1 N-(4-(N-benzoylsulfamoyl)phenylcarbamothioyl)-2-(4-bromo-2-chlorophenoxy) acetamide 
• 1449004-31-2 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-phenylacetylsulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-32-3 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(L-2-phenylglycyl)-sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-33-4 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-2-phenylglycyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-34-5 (S)-2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-2-(4-acetoxyphenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-35-6 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-36-7 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-Lphenylalanyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-37-8 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-L-3-(4-nitrophenyl)alanyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-38-9 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-carbobenzoxy-Ltryptophanyl)sulfamoyl)phenylcarbamothioyl)acetamide 
• 1449004-64-1 N-(4-(N-(L-leucyl)sulfamoyl)-phenylcarbamothioyl)-2-(4-bromo-2-chlorophenoxy) acetamide 

Relevant articles and documents

Discovery, synthesis and biological characterization of a series of: N -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1 H -pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as G protein-gated inwardly-rectifying potassium (GIRK) channel activators. From our previous lead optimization efforts, we have identified a new ether-based scaffold and paired this with a novel sulfone-based head group to identify a potent and selective GIRK1/2 activator. In addition, we evaluated the compounds in tier 1 DMPK assays and have identified compounds that display nanomolar potency as GIRK1/2 activators with improved metabolic stability over the prototypical urea-based compounds. This journal is

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

CDC42 INHIBITOR AND USES THEREOF

A compound having the structure of formula I and its use as a Cdc42 inhibitor. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and the experiments on cellular wound healing and on growth cone formation all demonstrate that the compound provided in the present invention is able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibited the effects of Cdc42 and effectively inhibit Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement.