1197420-29-3

Upstream product

• 1099665-13-0 1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol 
• 1197420-25-9 3,3-difluoro-1-((2-methoxy-4-nitrophenoxy)methyl)cyclobutanol 
• 1197420-24-8 5,5-difluoro-1-oxaspiro[2.3]hexane 
• 110654-33-6 1,1-difluoro-3-methylenecyclobutane 
• 1197420-23-7 1-(3,3-difluorocyclobutyl)-N,N-dimethylmethanamine oxide 
• 1197420-22-6 1-(3,3-difluorocyclobutyl)-N,N-dimethylmethanamine 
• 1197420-21-5 3,3-difluoro-N,N-dimethylcyclobutane-1-carboxamide 
• 515142-62-8 methyl 5-(4-chlorophenyl)-3-((dimethylamino)methyleneamino)thiophene-2-carboxylate 
• 1197420-11-3 6-(4-chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]-pyrimidin-4(3H)-one 
• 108549-23-1 Dibenzyl N,N-diisopropylphosphoramidite 

Downstream Products

• 1197420-12-4 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl dihydrogen phosphate 

Relevant academic research and scientific papers

Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor

The potent MCHR1 in vitro and in vivo antagonist activity of a series of cyclic tertiary alcohols derived from compound 2b is described. Subsequent pharmacokinetic and pharmacodynamic studies identified BMS-814580 (compound 10) as a highly efficacious antiobesity agent with a relatively clean in vitro and in vivo safety profile.

HYDROXY SUBSTITUTED THIENO PYRIMIDINONES AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present invention provides compounds having the following Formula IA and IB, which are useful as MCHR1 antagonists, and includes prodrugs and pharmaceutically acceptable salts thereof: