110654-66-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Nitrophenyl)MethanesulfonaMide is used as a synthetic intermediate for the production of disubstituted pyridine derivatives. These derivatives are known to be inhibitors of the protein cyclin-dependent kinase (CDK), which play a crucial role in regulating cell cycle progression. By inhibiting CDK, these pyridine derivatives can potentially be used in the development of therapeutic agents for the treatment of various diseases, including cancer.

Upstream product

• 58032-84-1 (3-nitrophenyl)methanesulfonyl chloride 
• 4563-33-1 phenyl-methanesulfonic acid amide 

Downstream Products

• 110654-39-2 N-(3-Sulfamoylmethyl-phenyl)-acetamide 
• 121-92-6 3-nitrobenzoic acid 
• 1073485-16-1 (3-(6-[2-(tetrahydro-furan-2-ylmethoxy)-phenyl]-pyrimidin-4-ylamino)-phenyl)-methanesulfonamide 
• 1073485-17-2 (3-(6-[2-(2-methoxy-ethoxy)-phenyl]-2-methyl-pyrimidin-4-ylamino)-phenyl)-methanesulfonamide 
• 1073484-96-4 (3-[2-amino-6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl)-methanesulfonamide 
• 1073485-15-0 (3-(6-[2-(2-methoxy-ethoxy)-phenyl]-pyrimidin-4-ylamino)-phenyl)-methanesulfonamide 
• 1073484-21-5 (3-[6-(2-ethoxy-phenyl)-pyrimidin-4-ylamino]-phenyl)-methanesulfonamide 
• 1073484-51-1 (3-[6-(2-ethyl-phenyl)-pyrimidin-4-ylamino]-phenyl)-methanesulfonamide 
• 344750-15-8 (3-aminophenyl)methanesulfonamide 
• 1073589-50-0 {3-[4-(2-methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-methanesulfonamide 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELLULAR PROLIFERATION

This invention is in the area of heterocyclic-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

METHODS FOR INHIBITING NECROPTOSIS

The present invention relates to methods for inhibiting necroptosis; screening methods for identifying compounds which inhibit necroptosis; and compounds for the inhibition of necroptosis, which may be useful in the treatment of conditions associated with deregulated necroptosis.

INHIBITORS OF PROTEIN KINASES

The present invention relates to inhibitors of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to methods of preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases comprising the administration of an effective amount of at least one inhibitor of cyclin-dependent kinases.

SULFONAMIDES

The invention relates to compounds of formula (I) wherein R1, R2, R4, Ra, Rb, Rc, Re, A*, W1, W2 and W3 are as defined in claim 1, for the treatment of CXCR3 related diseases.

INHIBITORS OF PROTEIN KINASES

The present invention relates to inhibitors of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to methods of preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases comprising the administration of an effective amount of at least one inhibitor of cyclin-dependent kinases.

4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES

The present invention relates to inhibitors of general Formula (I) of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to compounds for preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases.

NEW PYRIDINE ANALOGUES

The present invention relates to certain new pyridin analogues of Formula (I) Chemical formula should be inserted here. Please see paper copy Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.