110674-90-3Relevant academic research and scientific papers
AN APPROACH TO NOVEL ELLIPTICINE GLYCOSIDES
Langendoen, Albert,Koomen, Gerrit-Jan,Pandit, Upendra K.
, p. 3627 - 3632 (2007/10/02)
Reactions of 6-methylellipticine (3a) with the aim of preparing various functionalized derivatives have been studied.A base-(LDA) mediated reaction of 3a with formaldehyde results in a C(11)-hydroxyethyl derivative (3d), which has been coupled with ribose-, glucose- and galactose derivatives to give, after deprotection, novel ellipticine glycosides 3e-g.The sequene of reactions constitute a new strategy for the synthesis of a wide range of ellipticine derivatives with improved solubility characteristics.
SIDE-CHAIN SUBSTITUTION OF 6-METHYLELLIPTICINE APPROACH TO A NEW CLASS OF ELLIPTICINE DERIVATIVES
Langendoen, Albert,Koomen, Gerrit-Jan,Pandit, Upendra K.
, p. 69 - 73 (2007/10/02)
Reaction of 6- methylellipticine with lithium diisopropylamide results in deprotonation of the C11-CH3 group, generating an anion which reacts with formaldehyde to give the corresponding hydroxymethyl derivative.The latter has been converted into its riboside, glucoside and galactoside.
