18073-33-1

Basic information

• Product Name: 5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole
• Synonyms: 6H-pyrido[4,3-b]carbazole, 5,6,11-trimethyl-
• CAS NO: 18073-33-1
• Molecular Formula: C₁₈H₁₆N₂
• Molecular Weight: 260.333
• Mol File: 18073-33-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 478.9°C at 760 mmHg
• Flash Point: 243.4°C
• Density: 1.17g/cm³
• Vapor Pressure: 2.48E-09mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: 5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole(18073-33-1)
• EPA Substance Registry System: 5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole(18073-33-1)

Safety Data

• Hazardous Substances Data: 18073-33-1(Hazardous Substances Data)

Upstream product

• 84936-62-9 5-carbrthoxy-5,6-dimethyl-11-methylenepyrido<4,3-b>carbazole 
• 1326776-32-2 N'-tosyl-3-(2,2-diethoxyethylaminomethyl)-1,4,9-trimethyl-carbazole 
• 861207-74-1 9-formyl-1,4-dimethylcarbazole 
• 18024-11-8 1,4,9-trimethyl-9H-carbazole 
• 1065546-12-4 3-iodo-4-hydroxy-2,5-dimethylbenzaldehyde 
• 85231-15-8 4-formyl-2,5-dimethylphenol 
• 42308-20-3 2-bromopropionanilide 
• 95-87-4 2,5-Dimethylphenol 
• 62-53-3 aniline 
• 18073-26-2 3-(2,2-diethoxyethyliminomethyl)-1,4,9-trimethylcarbazole 
• 1618136-61-0 C₂₈H₃₃N₃O₆S 
• 1326776-30-0 3-(2,2-diethoxyethylaminomethyl)-1,4,9-trimethylcarbazole 
• 18073-18-2 1,4,9-trimethyl-9H-carbazole-3-carbaldehyde 
• 65266-47-9 N-(1,4-dimethylcarbazol-3-ylmethyl) aminoacetaldehyde diethyl acetal 

Downstream Products

• 154926-32-6 1-cyano-5,6,11-trimethylellipticine 
• 154926-27-9 1-cyano-2-p-tosyl-1,2-dihydro-5,6,11-trimethylellipticine 
• 1618136-72-3 2-(N-Boc-2-aminoethoxy)ethyl-9-hydroxy-6-methylellipticinium chloride 
• 1618136-76-7 2-(2-aminoethoxy)ethyl-9-hydroxy-6-methylellipticinium chloride 
• 1618136-81-4 C₂₄H₂₉N₄O₃⁽¹⁺⁾*Cl^(1-) 
• 1618136-86-9 C₂₄H₂₈N₅O₄⁽¹⁺⁾*Cl^(1-) 
• 1618136-73-4 2-(N-Boc-5-aminopentyl)-9-hydroxy-6-methylellipticinium chloride 
• 1618136-77-8 2-(5-aminopentyl)-9-hydroxy-6-methylellipticinium chloride 
• 1618136-82-5 Cl^(1-)*C₂₅H₃₁N₄O₂⁽¹⁺⁾ 
• 1618136-87-0 C₂₅H₃₀N₅O₃⁽¹⁺⁾*Cl^(1-) 
• 1618136-67-6 C₂₇H₃₄N₃O₄⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 1618136-69-8 C₂₈H₃₆N₃O₃⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 56501-52-1 6-methyl-9-hydroxyellipticine 
• 89651-48-9 11-hydroxymethyl-5,6-dimethyl pyrido<4,3-b>carbazole 

Relevant articles and documents

Basically substituted ellipticine analogues as potential antitumor agents

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Synthesis and cytotoxicity of novel bisellipticines and bisisoellipticines

A series of bis-ellipticines 7-9 and bis-isoellipticines 10-12 tethered through the indole nitrogen was synthesized and screened for antitumor cytotoxicity in the L-1210 murine leukemia assay. Activity was only displayed by 1,10-bis(6-ellipticinyl)-?-decane (8).

Synthesis method of natural product derivative 6-methylellipticine

The invention relates to a synthesis technology of a natural product derivative, and aims at providing a synthesis method of a natural product derivative 6-methylellipticine. The target molecule 6-methylellipticine is synthesized from a cheap and easily available raw material 2,5-dimethylphenol through formylation, iodination, propylene glycol protection, amidation, methylation, transition metal catalysis-free carbazole preparation, propylene glycol protection removal, reductive amination and acid-catalyzed cyclization. The above whole synthesis route is novel, unique and reasonable, and the 6-methylellipticine is synthesized from the 2,5-dimethylphenol without a transition metal catalyst, wherein the method for transition metal catalysis-free synthesis of key intermediates comprising a compound 5 and a compound 7 have not been reported in literatures. The synthesis method has the advantages of cheap and easily available raw materials, simplicity in operation, greenness, and great reduction of the production cost.