110680-41-6Relevant academic research and scientific papers
FACTOR XIa INHIBITORS
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, (2015/12/09)
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
THE ACID CATALYZED CYCLIZATION OF DIAZOKETONES: PREPARATION OF 2,4(3H,5H)FURANDIONES
Miller, R. D.,Theis, W.
, p. 1039 - 1042 (2007/10/02)
Diazoketones derived from substituted ethyl hydrogen malonates produced by the selective hydrolysis of the corresponding malonate esters cyclize in the presence of catalytic amounts of boron trifluoride etherate in methanol to yield 2,4(3H,5H)furandiones.The cyclic keto orthoesters appear to be intermediates in the reaction.
