22884-81-7Relevant academic research and scientific papers
Chemoselective reduction of 3-arylmethylidenetetrahydrofuran-2,4-diones with triethylsilane and sodium cyanotrihydridoborate in acid media
Pashkovskii,Shchukina,Lakhvich
experimental part, p. 858 - 862 (2010/01/03)
3-Arylmethylidenetetrahydrofuran-2,4-diones were smoothly reduced to the corresponding 3-benzyl derivatives in 50-98% yield with triethylsilane in trifluoroacetic acid or with sodium cyanotrihydridoborate in the system tetrahydrofuran-2 N hydrochloric aci
Methods of inhibiting the advanced glycosylation of proteins using tetramic and tetronic acids and compositions therefor
-
, (2008/06/13)
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises substituted or unsubstituted tetramic and tetronic acids capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
THE ACID CATALYZED CYCLIZATION OF DIAZOKETONES: PREPARATION OF 2,4(3H,5H)FURANDIONES
Miller, R. D.,Theis, W.
, p. 1039 - 1042 (2007/10/02)
Diazoketones derived from substituted ethyl hydrogen malonates produced by the selective hydrolysis of the corresponding malonate esters cyclize in the presence of catalytic amounts of boron trifluoride etherate in methanol to yield 2,4(3H,5H)furandiones.The cyclic keto orthoesters appear to be intermediates in the reaction.
