110684-43-0Relevant academic research and scientific papers
Copper-catalyzed decarboxylative regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles
Kumar, Navaneet,Ansari, Mohd Yeshab,Kant, Ruchir,Kumar, Atul
supporting information, p. 2627 - 2630 (2018/03/21)
A copper-catalyzed decarboxylative regioselective protocol for the synthesis of 1,5-disubstituted 1,2,3-triazoles through direct annulation of cinnamic acids with aryl azides has been developed. This is the first example of 1,5-disubstituted 1,2,3-triazoles, under aerobic conditions using Cu(ii) as the catalyst, which were generally synthesized using a ruthenium(ii) catalyst. The simplicity and regioselectivity of this methodology, complementing to the classical CuAAC catalyzed the synthesis of 1,4-disubstituted 1,2,3-triazoles.
A metal-free multicomponent cascade reaction for the regiospecific synthesis of 1,5-disubstituted 1,2,3-triazoles
Cheng, Guolin,Zeng, Xiaobao,Shen, Jinhai,Wang, Xuesong,Cui, Xiuling
, p. 13265 - 13268 (2014/01/06)
About specifics: A method for the regiospecific synthesis of the title compounds through an unprecedented Michael addition/deacylative diazo transfer/cyclization sequence has been established. The simple and practical method can be used for the modification of primary amines including chiral α-amines. The process involves the formation three covalent bonds and the cleavage of two covalent bonds (see scheme, Ts=4-toluenesulfonyl).
Ruthenium-catalyzed cycloaddition of aryl azides and alkynes
Rasmussen, Lars Kyhn,Boren, Brant C.,Fokin, Valery V.
, p. 5337 - 5339 (2008/09/17)
The formation of 1,5-disubstituted 1,2,3-triazoles from aryl azides and alkynes was readily accomplished using [Cp*RuCl]4 catalyst in dimethylformamide. It was also demonstrated that the reaction provided higher yields, cleaner product, and sho
Triazolines. 14. 1,2,3-Triazolines and Triazoles, a New Class of Anticonvulsants. Drug Design and Structure-Activity Relationships
Kadaba, Pankaja
, p. 196 - 203 (2007/10/02)
Pioneering studies in our laboratory have led to the emergence og the Δ2-1,2,3-triazolines (4,5-dihydro-1H-1,2,3-triazoles) and the closely related 1H-1,2,3-triazoles as a unique family of anticonvulsant agents hitherto unknown.Unlike the tradi
