110691-69-5

Basic information

• Product Name: (R*,S*)-1-benzyl-1,4-dihydro-7-(1,2-dihydroxy-3-methylbutyl)-4,6-dimethyl-9H-imidazo<1,2-a>purin-9-one
• CAS NO: 110691-69-5
• Molecular Weight: 395.461
• Mol File: 110691-69-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R*,S*)-1-benzyl-1,4-dihydro-7-(1,2-dihydroxy-3-methylbutyl)-4,6-dimethyl-9H-imidazo<1,2-a>purin-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R*,S*)-1-benzyl-1,4-dihydro-7-(1,2-dihydroxy-3-methylbutyl)-4,6-dimethyl-9H-imidazo<1,2-a>purin-9-one(110691-69-5)
• EPA Substance Registry System: (R*,S*)-1-benzyl-1,4-dihydro-7-(1,2-dihydroxy-3-methylbutyl)-4,6-dimethyl-9H-imidazo<1,2-a>purin-9-one(110691-69-5)

Safety Data

• Hazardous Substances Data: 110691-69-5(Hazardous Substances Data)

Upstream product

• 124927-18-0 <(1-benzyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purin-7-yl)methyl>triphenylphosphonium bromide 
• 124910-11-8 (E)-1-benzyl-1,4-dihydro-4,6-dimethyl-7-(3-methyl-1-butenyl)-9H-imidazo<1,2-a>purin-9-one 
• 96881-38-8 1-benzyl-1,4-dihydro-7-hydroxymethyl-4,6-dimethyl-9H-imidazo<1,2-a>purin-9-one 
• 96881-37-7 1-benzyl-7-formylwye 

Downstream Products

• 110691-70-8 trans-(+/-)-1-benzyl-1,4-dihydro-7-(5-isopropyl-2-oxo-1,3-dioxolan-4-yl)-4,6-dimethyl-9H-imidazo<1,2-a>purin-9-one 
• 110691-71-9 (+/-)-1-benzyl-7-(2-hydroxy-3-methylbutyl)-4,6-dimethyl-1,4-dihydro-9H-imidazo<1,2-a>purin-9-one 
• 110691-72-0 1-benzyl-1,4-dihydro-4,6-dimethyl-7-(3-methylbutyl)-9H-imidazo<1,2-a>purin-9-one 
• 124910-10-7 1-benzyl-7-(3-methyl-1-butenylwye) 
• 96881-37-7 1-benzyl-7-formylwye 

Relevant articles and documents

Studies towards the synthesis of the hypermodified nucleoside of rat liver phenylalanine transfer ribonucleic acid: Improved synthesis of the base β-hydroxywybutine

An improved synthesis of the key intermediates (3 and 8) for the synthesis of β-hydroxywybutines [[R(R*,S*)]- and [S-(R*,R*)]-4], the most probable structures for the minor base from rat liver tRNA(Phc), has been achieved by the Wittig reaction between 1-benzyl-7-formylwye (1) and the phosphorane derived from (R)-2[(methoxycarbonyl)amino]-3- (triphenylphosphonio)propanoate (10), followed by methylation, OsO4 oxidation, and cyclocondensation with COCI2 in the presence of pyridine. The racemic forms of β-hydroxywybutines [(R*,S*)- and (R*,R*)-4], which were required for the determination of the optical purity of [R-(R*,S*)]- and [S-(R*,R*)]-4 by means of chiral HPLC, were conveniently prepared through pyrolysis of the cyclic carbonate 3 followed by NaBH4 reduction and catalytic hydrogenolysis. The samples of [R-(R*,S*)]- and [S-(R*,R*)]-4 were thus shown to be optically pure.

Studies towards the synthesis of the fluorescent bases of phenylalanine transfer ribonucleic acids: Synthesis of 7-(2-hydroxy-3-methylbutyl)wye, a model for the minor base isolated from rat liver

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