110698-37-8Relevant academic research and scientific papers
Michael addition reaction of fluorinated nitro compounds
Huan, Feng,Hu, Huawei,Huang, Yangen,Chen, Qingyun,Guo, Yong
scheme or table, p. 798 - 802 (2012/05/20)
The Michael addition reactions of fluorinated nitro compounds with electron deficient olefins to give γ-fluoro-γ-nitro-esters, nitriles and ketones which bear a fluorinated quaternary carbon center were reported. The reactions were promoted by TMG, afford
Chemistry of Novel Compounds with Multifunctional Carbon Structure. 5. Molecular Design of Versatile Building Blocks for Aliphatic Monofluoro Molecules by Manipulation of Multifunctional Carbon Structure
Takeuchi, Yoshio,Nagata, Kazuhiro,Koizumi, Toru
, p. 5453 - 5459 (2007/10/02)
Three kinds of doubly functionalized monofluoromethylene fragments, 1-fluoro-1-nitro-1-(phenylsulfonyl)alkanes (10), 2-fluoro-2-(phenylsulfonyl)alkanoic esters (11), and 2-fluoro-2-nitroalkanoic esters (12), potentially versatile building blocks for the general synthesis of various aliphatic monofluoro molecules, were prepared from the corresponding difunctional compounds 1-3 by monoalkylation (R) and selective fluorinations.The interconversion or reductive removal of each functional group in 10-12 followed by the introduction of the second alkyl groups (R') at the fluorine-bearing carbon atom was examined.Compounds 12 proved to be useful and practical building blocks for conversions to the various monofluoroalkanes 20-26.
