1107616-89-6Relevant academic research and scientific papers
Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: Discovery and computational modeling of a new series of ligands with nanomolar affinity
Anighoro, Andrew,Graziani, Davide,Bettinelli, Ilaria,Cilia, Antonio,De Toma, Carlo,Longhi, Matteo,Mangiarotti, Fabio,Menegon, Sergio,Pirona, Lorenza,Poggesi, Elena,Riva, Carlo,Rastelli, Giulio
, p. 3040 - 3058 (2015)
Abstract Metabotropic glutamate receptor 5 (mGlu5) is a biological target implicated in major neurological and psychiatric disorders. In the present study, we have investigated structural determinants of the interaction of negative allosteric m
NOVEL HETEROCYCLIC DERIVATIVES AS M-GLU5 ANTAGONISTS
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Page/Page column 31, (2009/03/07)
This invention relates to novel heterocyclic compounds having selective affinity for the mGlu5 subtype of metabotropic receptors, pharmaceutical compositions thereof and uses for such compounds and compositions in the treatment of lower urinary tract diso
