Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: Discovery and computational modeling of a new series of ligands with nanomolar affinity

DOI: 10.1016/j.bmc.2015.05.008

Source and publish data:

Bioorganic and Medicinal Chemistry p. 3040 - 3058 (2015)

Update date:2022-08-03

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Authors:

Anighoro, Andrew

Graziani, Davide

Bettinelli, Ilaria

Cilia, Antonio

De Toma, Carlo

Longhi, Matteo

Mangiarotti, Fabio

Menegon, Sergio

Pirona, Lorenza

Poggesi, Elena

Riva, Carlo

Rastelli, Giulio

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Article abstract of DOI:10.1016/j.bmc.2015.05.008

Abstract Metabotropic glutamate receptor 5 (mGlu₅) is a biological target implicated in major neurological and psychiatric disorders. In the present study, we have investigated structural determinants of the interaction of negative allosteric m

Full text of DOI:10.1016/j.bmc.2015.05.008

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