110788-68-6Relevant articles and documents
Reaction of 2-Dimethyaminomethylene-1,3-diones with Dinucleophiles. II. Synthesis of 5-(Alkyl)(Phenyl)-4-acylisoxazoles and 6,7-Dihydro-1,2-benzisoxazol-4(5H)-ones
Menozzi, Giulia,Schenone, Pietro,Mosti, Luisa
, p. 645 - 648 (2007/10/02)
The reaction of open-chain and cyclohexane sym-2-dimethyaminomethylene-1,3-diones with hydroxylamine hydrochloride in refluxing methanol gave in good to moderate yields a series of 5-(alkyl)(phenyl)-4-acylisoxazoles and 6,7-dihydro-1,2-benzisoxazol-4(5H)-ones, respectively.As 3-unsubstituted isoxazoles, all these compounds easily isomerized with sodium methoxide to the corresponding 2-cyano-1,3-diones in high yields.