6497-21-8

Usage

Uses

Used in Organic Synthesis:
1-(5-METHYL-4-ISOXAZOLYL)-1-ETHAONE is used as a building block for the synthesis of various pharmaceutical drugs and agrochemicals, leveraging its structural and electronic characteristics to create novel compounds with potential therapeutic or agricultural benefits.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(5-METHYL-4-ISOXAZOLYL)-1-ETHAONE serves as an intermediate in the development of new bioactive compounds. Its unique properties allow researchers to explore its potential in creating innovative medications that address unmet medical needs.
Used in Medicinal Chemistry Research:
As a tool in medicinal chemistry, 1-(5-METHYL-4-ISOXAZOLYL)-1-ETHAONE aids in the investigation of compound interactions, mechanisms of action, and the optimization of drug candidates, contributing to the advancement of drug discovery and development processes.

InChI:InChI=1/C6H7NO2/c1-4(8)6-3-7-9-5(6)2/h3H,1-2H3

Upstream product

• 18856-72-9 3-dimethylaminomethylenepentane-2,4-dione 
• 123-54-6 acetylacetone 

Downstream Products

• 3141-59-1 2-acetyl-3-oxo-butyronitrile 
• 23340-25-2 α-benzal-β-ketobutyronitrile 
• 141-78-6 ethyl acetate 
• 6081-80-7 2-acetyl-3-phenylamino-2-butenenitrile 
• 108086-95-9 2-acetyl-3-methylamino-2-butenenitrile 
• 110788-68-6 2-Hydroxy-4-oxo-3-cyan-penten-(2) 
• 116545-46-1 1-(3-tert-Butylamino-5-methyl-1-phenyl-1H-pyrazol-4-yl)-ethanone 
• 31301-46-9 4-cyano-3,5-dimethylisoxazoline 
• 73225-34-0 4-cyano-3,5-dimethyl-1-(p)nitrophenylpyrazole 
• 108161-13-3 4-cyano-1,3,5-trimethylpyrazole 
• 108161-12-2 3,5-dimethyl-1H-pyrazole-4-carbonitrile 
• 23198-55-2 3,5-dimethyl-1-phenylpyrazole-4-carbonitrile 
• 681138-79-4 3-cyanohexa-2,4-dione 
• 941693-23-8 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbaldehyde 

Relevant academic research and scientific papers

An in situ combinatorial methodology to synthesize and screen chemical probes

Chemical probes that label proteins of interest in the context of complex biological samples are useful research tools. The reactive group that forms the covalent bond with the target protein has a large effect on the selectivity and selecting the appropriate group determines the success of a probe. We here report the development of a combinatorial methodology based on imine chemistry that enables straightforward in situ synthesis and screening of different reactive groups and thereby simplifies identification of probe leads. Using our methodology, we found chemical probes targeting BirA and chloramphenicol acetyl transferase, two proteins associated with antibacterial activity and resistance.

Total synthesis of anibamine, a novel natural product as a chemokine receptor CCR5 antagonist

The total synthesis of anibamine, the first and only natural product known as a chemokine receptor OCR5 antagonist, is reported herein. Anibamine was synthesized from acetylacetone and cyanoacetamide in 10 steps.

Isoxazolyl indolamines

This disclosure describes compounds of the formula STR1 where R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 represents hydroxy, and R3 and R4 each independently represent lower alkyl as defined above, or R3 and R4 together with N represent STR2 wherein n is 1, 2, or 3, and R5 and R6 each independently represent hydrogen or lower alkyl as defined above, and R7 represents lower alkyl as defined above, or a pharmaceutically acceptable acid addition salt thereof, which are useful as anti-diabetic agents, in particular as hypoglycemic agents and inhibiting or impeding postprandial hyperglycemia.

Reaction of 2-Dimethyaminomethylene-1,3-diones with Dinucleophiles. II. Synthesis of 5-(Alkyl)(Phenyl)-4-acylisoxazoles and 6,7-Dihydro-1,2-benzisoxazol-4(5H)-ones

The reaction of open-chain and cyclohexane sym-2-dimethyaminomethylene-1,3-diones with hydroxylamine hydrochloride in refluxing methanol gave in good to moderate yields a series of 5-(alkyl)(phenyl)-4-acylisoxazoles and 6,7-dihydro-1,2-benzisoxazol-4(5H)-ones, respectively.As 3-unsubstituted isoxazoles, all these compounds easily isomerized with sodium methoxide to the corresponding 2-cyano-1,3-diones in high yields.

Isoxazolyl indolamines

This disclosure describes compounds of the formula STR1 where R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 represents hydroxy, and R3 and R4 each independently represent lower alkyl as defined above, or R3 and R4 together with N represent STR2 wherein n is 1, 2 or 3, and R5 and R6 each independently represent hydrogen or lower alkyl as defined above, or a pharmaceutically acceptable acid addition salt thereof, which are useful as anti-diabetic agents, in particular as hypoglycemic agents and inhibiting or impeding post-prandial hyperglycemia.

Isoxazolyl indolamines

This disclosure describes compounds of the formula STR1 where R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 and R3 each independently repr