1108-68-5

Basic information

• Product Name: Cinobufotalin
• Synonyms: 5BETA,20[22]-BUFADIENOLIDE-14,15BETA-EPOXY-3BETA,5ALPHA,16BETA-TRIOL 16-ACETATE;14,15-beta-epoxy-3-beta,5,16-beta-trihydroxy-22-dienolid16-5-beta-bufa-2;cinobufotalin venom toad;Cinobufotalin std.;CINOBUFOTALIN(RG);14,15b-Epoxy-3b,5a,16b-trihydroxy-5b,20(22)-bufadienolide 16-acetate;5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate, 14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate;14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
• CAS NO: 1108-68-5
• Molecular Formula: C₂₆H₃₄O₇
• Molecular Weight: 458.54
• Mol File: 1108-68-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 259-262°
• Boiling Point: 627.3 ºC at 760 mmHg
• Flash Point: 210.7 ºC
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 2.28E-18mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• PKA: 14.67±0.70(Predicted)
• CAS DataBase Reference: Cinobufotalin(CAS DataBase Reference)
• NIST Chemistry Reference: Cinobufotalin(1108-68-5)
• EPA Substance Registry System: Cinobufotalin(1108-68-5)

Safety Data

• Hazard Codes: T+
• Statements: 26/27/28
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: EI2991000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 1108-68-5(Hazardous Substances Data)

Usage

General Description

Cinobufotalin is a chemical compound found in the venom of the Chinese toad, Bufo gargarizans and Bufo bufo. It is a type of bufadienolide, which is a class of organic compounds that belong to the steroid family. Cinobufotalin has been traditionally used in Chinese medicine for its cardiotonic, anti-inflammatory, and anti-tumor properties. It has been studied for its potential anticancer activities, particularly in liver, lung, and colon cancer cells. Additionally, it has been investigated for its potential in treating cardiac conditions, such as heart failure and arrhythmias. However, it is important to note that cinobufotalin can be toxic and should only be used under the guidance of a qualified healthcare professional.

InChI:InChI=1/C26H34O7/c1-14(27)32-21-20(15-4-5-19(29)31-13-15)24(3)10-7-17-18(26(24)22(21)33-26)8-11-25(30)12-16(28)6-9-23(17,25)2/h4-5,13,16-18,20-22,28,30H,6-12H2,1-3H3/t16-,17-,18+,20-,21+,22+,23+,24+,25-,26+/m0/s1

Upstream product

• 470-37-1 cinobufagin 
• 1030609-22-3 cinobufotalin 3-nonanedioylarginine ester 

Related news

Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and Cinobufotalin (cas 1108-68-5) by digibind: Monitoring the effect by measuring free digitoxin concentrations08/15/2019

Oleandrin plant poisoning is common in children and the plant extract is used in Chinese medicines. The toxicity is due to oleandrin and the deglycosylated metabolite oleandrigenin. Bufalin and cinobufotalin (toad cardiac toxins) are also widely used in Chinese medicines like Chan SU, and Lu-She...detailed

Microbial transformation of Cinobufotalin (cas 1108-68-5) by Alternaria alternate AS 3.4578 and Aspergillus niger AS 3.73908/13/2019

Cinobufotalin (1), a major bioactive bufadienolide, has the potential anti-cancer activity. In the present paper, a scaled-up biotransformation of 1 by Aspergillus niger AS 3.739 and Alternaria alternate AS 3.4578 was performed for improving its biological activities and water-solubility. Seven ...detailed

Pre-clinical evaluation of Cinobufotalin (cas 1108-68-5) as a potential anti-lung cancer agent08/12/2019

Lung cancer is a major cause of cancer-related mortality in the United States and around the world. Due to the pre-existing or acquired chemo-resistance, the current standard chemotherapy regimens only show moderate activity against lung cancer. In the current study, we explored the potential an...detailed

Relevant articles and documents

Studies on cytotoxic constituents from the skin of the toad Bufo bufo gargarizans

To study the chemical composition of the skin of Bufo bufo gargarizans, many kinds of chromatography methods were used in the isolation procedures, while the structures of isolated compounds were determined on the basis of their NMR and MS spectral analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as cinobufotalin 3-nonanedioylarginine ester (8) and bufotalin 3-pimeloylarginine ester (14). Furthermore, 13 known compounds were obtained. Isolated bufadienolides showed significant inhibition effect against SMMC-7721 cell lines in vitro.