Welcome to LookChem.com Sign In|Join Free
  • or
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.

470-37-1

Post Buying Request

470-37-1 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

470-37-1 Usage

References

1. https://en.wikipedia.org/wiki/Cinobufagin 2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412 3. http://www.yourdictionary.com/cinobufagin 4. https://www.medchemexpress.com/cinobufagin.html

Uses

Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.

Check Digit Verification of cas no

The CAS Registry Mumber 470-37-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 470-37:
(5*4)+(4*7)+(3*0)+(2*3)+(1*7)=61
61 % 10 = 1
So 470-37-1 is a valid CAS Registry Number.
InChI:InChI=1/C26H34O6/c1-14(27)31-22-21(15-4-7-20(29)30-13-15)25(3)11-9-18-19(26(25)23(22)32-26)6-5-16-12-17(28)8-10-24(16,18)2/h4,7,13,16-19,21-23,28H,5-6,8-12H2,1-3H3/t16-,17+,18+,19-,21+,22-,23-,24+,25-,26-/m1/s1

470-37-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Sigma

  • (C1272)  Cinobufagin  

  • 470-37-1

  • C1272-1MG

  • 498.42CNY

  • Detail

470-37-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Cinobufagin

1.2 Other means of identification

Product number -
Other names CINOBUFAGIN(P)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:470-37-1 SDS

470-37-1Relevant academic research and scientific papers

Probing the stereoselectivity of OleD-catalyzed glycosylation of cardiotonic steroids?

Zhu, Xue-Lin,Wen, Chao,Ye, Qing-Mei,Xu, Wei,Zou, Deng-Lang,Liang, Guang-Ping,Zhang, Fan,Chen, Wan-Na,Jiang, Ren-Wang

, p. 5071 - 5078 (2018/02/09)

The glycosyltransferase OleD variant as a catalyst for the glycosylation of four pairs of epimers of cardiotonic steroids (CTS) are assessed. The results of this study demonstrated that the OleD-catalyze glycosylation of CTS is significantly influenced by

SYNTHESIS OF 5α-CINOBUFAGIN

Kamano, Yoshiaki,Drasar, Pavel,Pettit, George R.,Tozawa, Machiko

, p. 1325 - 1330 (2007/10/02)

Cinobufagin (I) and cinobufotalin (IV) isolated from the Chinese toad venom preparation Ch'an Su were used as starting points for synthesis of 5α-cinobufagin (III) via the 3-oxo-4-ene derivative VII.Lithium borohydride reduction of ketone VII afforded 5α-cinobufagin (III) accompanied by 3-epicinobufagin (IX).Ring A diene II, was obtained as one of the dichlorodicyanobenzoquinone oxidation products of 3-oxocinobufagin (V).

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 470-37-1