110814-91-0Relevant articles and documents
NEW SAYNTHESES OF 1-AMINO- AND 1-(2-AMINOETHYL)-2,6-DICYANOPIPERIDINES AND DIAZABICYCLO COMPOUNDS BY A STRECKER REACTION USING GLUTARALDEHYDE AND DIAMINES, AND THEIR STEREOCHEMISTRY
Takahashi, Kazumasa,Tachiki, Akira,Ogura, Katsuyuki,Iida, Hirotada
, p. 2835 - 2840 (2007/10/02)
An efficient sequence proposed here involves a simple Strecker reaction of glutaraldehyde with hydrazine or 1,2-diaminoethane, which gives 1-amino- or 1-(2-aminoethyl)2,6-dicyanopiperidines, 2-cyano-1,7-diazabicyclononane, and 10-cyano-1,4-diazabicyclodecan-5-one.Their stereochemistry is also elucidated.Moreover, treatment of 1-amino-2,6-dicyanopiperidine and phthaloyl dichloride in the presence of 4-(N,N-dimethylamino)pyridine quantitatively gives 1-phthalimido-2,6-dicyanopiperidine.