1108164-37-9

Basic information

• Product Name: 1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-ol
• Synonyms: 1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-ol
• CAS NO: 1108164-37-9
• Molecular Formula: C₉H₁₂ClN₃O
• Molecular Weight: 213.66408
• Mol File: 1108164-37-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-ol(1108164-37-9)
• EPA Substance Registry System: 1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-ol(1108164-37-9)

Safety Data

• Hazardous Substances Data: 1108164-37-9(Hazardous Substances Data)

Usage

General Description

1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-ol is a chemical compound with the molecular formula C11H14ClN3O. It is a piperidine derivative with a chloro-pyrimidine moiety attached to the piperidine ring. 1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-ol has potential pharmaceutical applications due to its structural features and functional groups, which may allow it to interact with biological targets and exhibit pharmacological activities. Further research and development may be warranted to explore the potential uses and properties of 1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-ol in various medical and scientific fields.

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 22536-67-0 2,5-dichloropyrimidine 
• 874676-81-0 5-chloro-2-iodopyrimidine 

Downstream Products

• 1020658-32-5 5-{2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}nicotinic acid 
• 1020658-67-6 ethyl 3-{2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}benzoate 
• 1339944-48-7 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(3-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one 
• 1339944-56-7 5-Chloro-4-(1-(5-chloropyrimidin-2-yl)piperidin-4-yloxy)-1-(4-(ethylsulfonyl)-3-fluorophenyl)pyridin-2(1H)-one 
• 1339944-55-6 5-Chloro-4-(1-(5-chloropyrimidin-2-yl)piperidin-4-yloxy)-1-(4-(ethylsulfonyl)-2-fluorophenyl)pyridin-2(1H)-one 
• 1339944-45-4 5-chloro-4-(1-(5-chloropyrimidin-2-yl)piperidin-4-yloxy)-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one 

Relevant articles and documents

Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1 H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119

G-protein-coupled receptor 119 (GPR119) is expressed predominantly in pancreatic β-cells and in enteroendocrine cells in the gastrointestinal tract. GPR119 agonists have been shown to stimulate glucose-dependent insulin release by direct action in the pancreas and to promote secretion of the incretin GLP-1 by action in the gastrointestinal tract. This dual mechanism of action has generated significant interest in the discovery of small molecule GPR119 agonists as a potential new treatment for type 2 diabetes. Herein, we describe the discovery and optimization of a new class of pyridone containing GPR119 agonists. The potent and selective BMS-903452 (42) was efficacious in both acute and chronic in vivo rodent models of diabetes. Dosing of 42 in a single ascending dose study in normal healthy humans showed a dose dependent increase in exposure and a trend toward increased total GLP-1 plasma levels.

PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES AS GPR119 MODULATORS

Novel compounds of structure Formula I: or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein n1, R1, R2, R3 and R4 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.