1020658-67-6Relevant articles and documents
Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy
Powell, David A.,Black, W. Cameron,Bleasby, Kelly,Chan, Chi-Chung,Deschenes, Denis,Gagnon, Marc,Gordon, Rob,Guay, Jocelyne,Guiral, Sebastien,Hafey, Michael J.,Huang, Zheng,Isabel, Elise,Leblanc, Yves,Styhler, Angela,Xu, Li-Jing,Zhang, Lei,Oballa, Renata M.
scheme or table, p. 7281 - 7286 (2012/02/15)
An in vitro screening protocol was used to transform a systemically- distributed SCD inhibitor into a liver-targeted compound. Incorporation of a key nicotinic acid moiety enables molecular recognition by OATP transporters, as demonstrated by uptake studi