110824-17-4Relevant academic research and scientific papers
Enantioselective Synthesis of β-Necrodol and of 1-Epi-β-necrodol via Asymmetric 1,4-Addition and Magnesium-Ene Cyclization
Oppolzer, Wolfgang,Schneider, Philippe
, p. 1817 - 1820 (1986)
Enantiomerically pure β-necrodol (1) and its 1-epimer 16 have been synthesized starting from aldehyde 5.The two key steps are an asymmetric conjugate addition/Mannich reaction tandem (10->12) and a type-II-magnesiumene cyclization/oxidation sequence (14->1 + 16).
