Enantioselective Synthesis of β-Necrodol and of 1-Epi-β-necrodol via Asymmetric 1,4-Addition and Magnesium-Ene Cyclization

DOI: 10.1002/hlca.19860690805

Source and publish data:

Helvetica Chimica Acta p. 1817 - 1820 (1986)

Update date:2022-09-26

Topics:

Authors:

Oppolzer, Wolfgang

Schneider, Philippe

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/hlca.19860690805

Enantiomerically pure β-necrodol (1) and its 1-epimer 16 have been synthesized starting from aldehyde 5.The two key steps are an asymmetric conjugate addition/Mannich reaction tandem (10->12) and a type-II-magnesiumene cyclization/oxidation sequence (14->1 + 16).

Full text of DOI:10.1002/hlca.19860690805

Products guided by the article

Product name:(E)-4,4-Dimethyl-hexa-2,5-dienoic acid cyclohexyl ester

Cas No:110824-17-4

R&D Labs maybe for 110824-17-4

Beijing Chemdow Co., Ltd

website:http://www.chemdow.com

Contact:0086-10-82435335

Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
Shanghai Xinda Pharmaceuticals Co., Ltd.

Contact:86-21-33692333-8008

Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
Anhui Hope-Chem Co., Ltd.

Contact:86-551-63540590

Address:No 1388 Furong Rd., Hefei, Anhui, China
Henan PURUI Pharmaceutical Co., Ltd.

website:http://www.puruipharm.com

Contact:17739583555

Address:Yezhuangqiao,Xihua town, Henan province

Relevant to this article

Synthesis of Novel 2-Amino-4-aryl-5-arylthio-6-methoxypyrimidines and 3(5)-Aryl-4-arylthio-5(3)-methylthiopyrazoles via α-Oxo-α-arylthioketene dithioacetals

Doi:10.1055/s-1987-27920
(1987)
Design, synthesis, and insecticidal activities of novel analogues of neonicotinoids: Replacement of nitromethylene with nitroconjugated system

Doi:10.1021/jf803305f
(2009)
Doi:10.1021/jo01100a001
(1958)
Pd(II)/(S)-t-BuPyOx-catalyzed asymmetric addition of arylboronic acids to N-sulfonyl-arylaldimines

Doi:10.1016/j.tetlet.2021.153057
(2021)
Studies on lignan lactone antitumor agents. I. Synthesis of aminoglycosidic lignan variants related to podophyllotoxin

Doi:10.1248/cpb.34.3733
(1986)
Reversible light-induced magnetization change in an azobenzene-attached pyridylbenzimidazole complex of iron(II) at room temperature

Doi:10.1039/b817196n
(2009)

Article Doi