Enantioselective Synthesis of β-Necrodol and of 1-Epi-β-necrodol via Asymmetric 1,4-Addition and Magnesium-Ene Cyclization

DOI: 10.1002/hlca.19860690805

Source and publish data:

Helvetica Chimica Acta p. 1817 - 1820 (1986)

Update date:2022-09-26

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Authors:

Oppolzer, Wolfgang

Schneider, Philippe

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Article abstract of DOI:10.1002/hlca.19860690805

Enantiomerically pure β-necrodol (1) and its 1-epimer 16 have been synthesized starting from aldehyde 5.The two key steps are an asymmetric conjugate addition/Mannich reaction tandem (10->12) and a type-II-magnesiumene cyclization/oxidation sequence (14->1 + 16).

Full text of DOI:10.1002/hlca.19860690805

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