1108593-76-5Relevant academic research and scientific papers
Synthesis and evaluation of isomers of melleumin B from the myxomycete Physarum melleum; an approach for Wnt signal inhibitor trusted in nature
Arai, Midori A.,Uchino, Yujiro,Hanazawa, Shuwa,Li, Xiaofan,Kimura, Naoki,Ishibashi, Masami
, p. 1425 - 1438 (2008)
Two stereoisomers of melleumin B (1), seco acid methyl ester of melleumin A (2), which are novel peptide compounds isolated from the myxomycete Physarum melleum, were synthesized and evaluated for their inhibition of Wnt signal transcription. The 3R-epimer and (3R, 4S, 10R, 11R)-isomer of 1 showed moderate inhibition of the Wnt signal.
