1108615-32-2Relevant academic research and scientific papers
Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1
Varnes, Jeffrey G.,Xiong, Hui,Forst, Janet M.,Holmquist, Christopher R.,Ernst, Glen E.,Frietze, William,Dembofsky, Bruce,Andisik, Don W.,Palmer, William E.,Hinkley, Lindsay,Steelman, Gary B.,Wilkins, Deidre E.,Tian, Gaochao,Jonak, Gerald,Potts, William M.,Wang, Xia,Brugel, Todd A.,Alhambra, Cristóbal,Wood, Michael W.,Veale, Chris A.,Albert, Jeffrey S.
, p. 1043 - 1049 (2018/03/01)
A series of isoquinuclidine benzamides as glycine uptake inhibitors for the treatment of schizophrenia are described. Potency, lipophilicity, and intrinsic human microsomal clearance were parameters for optimization. Potency correlated with the nature of
