1108730-15-9Relevant academic research and scientific papers
A domino reaction of a β-ketoester, phenylethylamine and ethyl glyoxylate: leading to chiral tricarboxylate containing multiple stereocenters
Huang, Xiaoguang,Chen, Xueming,Chen, Yunyun,Zhang, Aiqin,Li, Xingshu
scheme or table, p. 2529 - 2535 (2009/04/04)
A new type of chiral tricarboxylate containing multiple stereocenters was synthesized via the one-pot reaction of a β-ketoester, (S)-phenylethylamine, and ethyl glyoxylate. High yields and diastereoselectivities (up to 96:4 dr) were obtained under optimal conditions. The reaction of the chiral tricarboxylate with Zn(BH4)2 gave chiral γ-lactones in good yields with up to 92:8 dr. The structures and configurations of the new chiral tricarboxylates were characterized by X-ray diffraction analysis.
