1108730-68-2Relevant academic research and scientific papers
Solid-supported gallium triflate: An efficient catalyst for the three-component ketonic strecker reaction
Wiles, Charlotte,Watts, Paul
, p. 332 - 338 (2012)
In light of the growing interest in the use of rare earth metal triflates as water-tolerant Lewis acid catalysts, we embarked upon the development of a solid-supported gallium triflate (PS-Ga(OTf)2) derivative as a means of increasing the clean
Evaluation of the heterogeneously catalyzed strecker reaction conducted under continuous flow
Wiles, Charlotte,Watts, Paul
experimental part, p. 5597 - 5613 (2009/05/11)
Building on our experience of micro-reaction technology, we present herein the evaluation of an integrated borosilicate glass micro reactor in which 51 α-aminonitriles were synthesized via a series of continuous solution-phase and heterogeneously catalyzed reaction steps, affording analytically pure products in yields > 99.6%. As an extension to this, the ability to selectivity synthesize aldehydic Strecker products in the presence of ketonic functionalities was also investigated, concluding with the chemoselective synthesis of 2-(4-acetylphenyl)-2-(phenethylamino)acetonitrile whereby the desired product was obtained in 99.8% yield and quantitative purity. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
