1108730-74-0Relevant academic research and scientific papers
L-Proline catalyzed one pot synthesis of α-aminonitriles
Nasreen, Aayesha
, p. 3797 - 3800 (2013/07/05)
l-Proline (20 mol %) was found to be an efficient organocatalyst for one pot synthesis of a variety of α-aminonitriles from aldehydes, amines, and trimethylsilyl cyanide (TMSCN) in acetonitrile at ambient temperature giving good to excellent yields (72-95%).
Synthesis of iminonitriles by oxone/tbab-mediated one-pot oxidative three-component strecker reaction
Gualtierotti, Jean-Baptiste,Schumacher, Xavier,Wang, Qian,Zhu, Jieping
, p. 1380 - 1386 (2013/07/05)
Oxidative three-component reaction of aldehydes, amines, and TMSCN in a biphasic solvent system (toluene/H2O) containing Oxone, tetra-n-butylammonium bromide (TBAB) and sodium bicarbonate afforded α-iminonitriles in good to excellent yields. This oxidative Strecker reaction was applicable to a wide range of aldehydes and amines, aromatic or aliphatic, of different electronic and steric properties. Substituted 1-aza-2-cyano-1,3-dienes were also accessible using α,β-unsaturated aldehydes as inputs.
