1108734-79-7Relevant academic research and scientific papers
Efficient one-pot synthesis of 1,3-disubstituted pyridin-2(1H)-ones from α-hydroxyketene S, S-acetals under Vilsmeier conditions
Liu, Jun,Liang, Deqiang,Wang, Mang,Liu, Qun
scheme or table, p. 3633 - 3638 (2009/07/04)
A facile and efficient one-pot synthesis of 1,3-disubstituted pyridin-2(1H)-ones is developed via a novel cascade reaction of readily available α-hydroxy-α-carbamoyl ketene S,S-acetals under Vilsmeier conditions (DMF/POCl3), and a mechanism of this domino reaction is proposed. Georg Thieme Verlag Stuttgart · New York.
