929604-66-0Relevant academic research and scientific papers
BF3·OEt2-mediated C-C bond-forming reaction of α-hydroxyketene-(S,S)-acetals with active methylene compounds and its application in the synthesis of substituted 3,4-dihydro-2-pyridones
Liu, Jun,Liang, Fushun,Liu, Qun,Li, Bing
, p. 156 - 160 (2007)
The C-C bond-forming reaction between α-hydroxyketene-(S,S)-acetals 2 and active methylene compounds is described. Mediated by boron trifluoride etherate (BF3·OEt2), a series of C-C bond coupling products, 2-(2-acetyl-1-methyl-3-oxob
Palladium-catalyzed c-S activation/aryne insertion/coupling sequence: Synthesis of functionalized 2-quinolinones
Dong, Ying,Liu, Bangyu,Chen, Peng,Liu, Qun,Wang, Mang
supporting information, p. 3442 - 3446 (2014/04/03)
The insertion of an aryne into a C-S bond can suppress the addition of an S nucleophile to the aryne in the presence of palladium. Catalyzed by Pd(OAc)2, a wide range of α-carbamoyl ketene dithioacetals readily react with arynes to selectively afford functionalized 2-quinolinones in high yields under neutral reaction conditions by a C-S activation/aryne insertion/intramolecular coupling sequence. The attractive feature of the new strategy also lies in the versatile transformations of the alkythio-substituted quinolinone products. Within range: Under palladium catalysis a wide range of α-carbamoyl ketene dithioacetals readily react with arynes to selectively afford 2-quinolinones in high yields under neutral reaction conditions by the title sequence (see scheme). An attractive feature of the new strategy also lies in the versatile transformations of the alkylthio-substituted quinolinones.
Sulfuric acid-catalyzed regioselective alkylation of indoles and β-naphthols with ketene dithioacetal-based allylic alcohols
Wang, Mang,Sun, Shaoguang,Liang, Deqiang,Liu, Bangyu,Dong, Ying,Liu, Qun
, p. 2466 - 2473 (2011/06/10)
A novel catalytic alkylation of indoles with allylic alcohols has been developed. Catalyzed by sulfuric acid (10 mol-%), the reaction between indoles 2 and allylic alcohols 1 based on ketene dithioacetal affords polyfunctionalized indoles 3 in good to exc
AlCl3-mediated direct carbon-carbon bond-forming reaction of α-hydroxyketene-S,S-acetals with arenes and synthesis of 3,4-disubstituted dihydrocoumarin derivatives
Piao, Cheng-Ri,Zhao, Yu-Long,Han, Xiao-Dan,Liu, Qun
, p. 2264 - 2269 (2008/09/19)
A simple and efficient AlCl3-mediated C-C coupling reaction between readily available α-hydroxyketene-S,S-acetals and various arenes via direct substitution of the hydroxy group in alcohols has been developed. On the basis of this C-C coupling reaction, a series of bio- and pharmacologically important 3,4-disubstituted dihydrocoumarins, difficult to obtain by other methods, were prepared in high yields by a sequential Friedel-Crafts alkylation and intramolecular annulation reaction of α-hydroxyketene acyclic-S,S-acetals with phenols under mild conditions.
