1108736-45-3Relevant academic research and scientific papers
Ethyl 2,2-bis(4-methylphenylsulfonamido)acetate to aromatic α-amino acids: Stable substrates for catalytic arylation reactions
Marques, Carolina S.,Burke, Anthony J.
, p. 10091 - 10097 (2013)
This paper reports the development of a novel methodology for the catalytic synthesis of aromatic α-amino acids, which involves the addition of aryl-organoboron reagents to α,α-ditosylamino esters derived from ethyl glyoxylate, using transition metal catalysts, like Rh and Pd. A library of α-amino esters (12 with Pd and 8 with Rh), was synthesized with moderate to excellent yields. A highest enantioselectivity of 30% ee was obtained using Hayashi's ligand. This method was applied to the synthesis of phenylglycine.
An efficient synthesis of azetidines with (2-bromoethyl)sulfonium triflate
Fritz, Sven P.,Moya, Juan F.,Unthank, Matthew G.,Mcgarrigle, Eoghan M.,Aggarwal, Varinder K.
experimental part, p. 1584 - 1590 (2012/06/29)
Easily accessible arylglycine derivatives were cyclized to azetidines by using commercially available (2-bromoethyl)sulfonium triflate in a simple and mild procedure. The high-yielding reaction has a relatively broad scope and was extended to the synthesi
