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110874-83-4

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110874-83-4 Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 5621, 1987 DOI: 10.1021/jo00234a021Tetrahedron Letters, 25, p. 5283, 1984 DOI: 10.1016/S0040-4039(01)81584-7

Check Digit Verification of cas no

The CAS Registry Mumber 110874-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,8,7 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 110874-83:
(8*1)+(7*1)+(6*0)+(5*8)+(4*7)+(3*4)+(2*8)+(1*3)=114
114 % 10 = 4
So 110874-83-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H14O3/c1-3-4-5-6-8(10)7-9(11)12-2/h3-4H,5-7H2,1-2H3/b4-3+

110874-83-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name METHYL 3-OXO-6-OCTENOATE

1.2 Other means of identification

Product number -
Other names predominantlytrans

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:110874-83-4 SDS

110874-83-4Downstream Products

110874-83-4Relevant articles and documents

The Discovery of (S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H -inden-4-yl)pyridin-2-yl)-5-methyl-1 H -pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma

Ehara, Takeru,Adams, Christopher M.,Bevan, Doug,Ji, Nan,Meredith, Erik L.,Belanger, David B.,Powers, James,Kato, Mitsunori,Solovay, Catherine,Liu, Donglei,Capparelli, Michael,Bolduc, Philippe,Grob, Jonathan E.,Daniels, Matthew H.,Ferrara, Luciana,Yang, Louis,Li, Byron,Towler, Christopher S.,Stacy, Rebecca C.,Prasanna, Ganesh,Mogi, Muneto

, p. 2552 - 2570 (2018/03/26)

Soluble guanylate cyclase (sGC), the endogenous receptor for nitric oxide (NO), has been implicated in several diseases associated with oxidative stress. In a pathological oxidative environment, the heme group of sGC can be oxidized becoming unresponsive to NO leading to a loss in the ability to catalyze the production of cGMP. Recently a dysfunctional sGC/NO/cGMP pathway has been implicated in contributing to elevated intraocular pressure associated with glaucoma. Herein we describe the discovery of molecules specifically designed for topical ocular administration, which can activate oxidized sGC restoring the ability to catalyze the production of cGMP. These efforts culminated in the identification of compound (+)-23, which robustly lowers intraocular pressure in a cynomolgus model of elevated intraocular pressure over 24 h after a single topical ocular drop and has been selected for clinical evaluation.

Rh2(II)-catalyzed ester migration to afford 3 H-indoles from trisubstituted styryl azides

Kong, Chen,Driver, Tom G.

supporting information, p. 802 - 805 (2015/04/27)

Rh2(II)-Complexes trigger the formation of 3H-indoles from ortho-alkenyl substituted aryl azides. This reaction occurs through a 4π-electron-5-atom electrocyclization of the rhodium N-aryl nitrene followed by a [1,2]-migration to afford only 3H-indoles. The selectivity of the migration is dependent on the identity of the β-styryl substituent.

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