1108741-87-2Relevant academic research and scientific papers
Synthesis of substituted indoles from 2-azidoacrylates and ortho-silyl aryltriflates
Hong, Deng,Chen, Zhengbo,Lin, Xufeng,Wang, Yanguang
supporting information; experimental part, p. 4608 - 4611 (2010/12/18)
2-Azidoacrylates react with benzynes in the presence of PPh3 and CsF to afford substituted indoles in good yields. The reaction involves the formation of iminophosphorane and benzyne and a subsequent double cyclization/hydrolysis/air-oxidation cascade. This methodology was utilized to synthesize 10H-indolo[1,2-a]indol-10-ones.
Novel method for synthesis of aryl hydrazones from α-diazo esters: scope and limitations of nucleophiles
Yasui, Eiko,Wada, Masao,Takamura, Norio
experimental part, p. 461 - 468 (2009/04/06)
Aryl hydrazones, the precursor of Fischer indole synthesis, were easily obtained by nucleophilic addition of aryllithium reagents to diazo esters. The aryl hydrazones were converted into indoles in good yields by heating with thionyl chloride in alcohol.
