110878-71-2

Basic information

• Product Name: 4-(3-HYDROXYPHENYL)PIPERIDINE
• Synonyms: 4-(3-HYDROXYPHENYL)PIPERIDINE;3-(4-PIPERIDYL)PHENOL;Hydroxyphenylpiperadine;4-(3-HYDROXYPHENYL)PIPERIDINE 98+%;3-Piperidin-4-yl-phenol;3-(4-Piperidinyl)phenol
• CAS NO: 110878-71-2
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 110878-71-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 225°C
• Boiling Point: 320.9°Cat760mmHg
• Flash Point: 139.8°C
• Appearance: /
• Density: 1.073g/cm³
• PKA: 9.85±0.10(Predicted)
• CAS DataBase Reference: 4-(3-HYDROXYPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-HYDROXYPHENYL)PIPERIDINE(110878-71-2)
• EPA Substance Registry System: 4-(3-HYDROXYPHENYL)PIPERIDINE(110878-71-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 110878-71-2(Hazardous Substances Data)

Usage

General Description

4-(3-Hydroxyphenyl)piperidine is a chemical compound with the molecular formula C13H17NO. It is a synthetic organic compound that belongs to the class of piperidines, which are nitrogen-containing heterocyclic compounds. The compound features a piperidine ring with a hydroxyphenyl group attached to the fourth position. This chemical is commonly used in medicinal chemistry and pharmacological research, where it serves as a building block for the synthesis of various pharmaceuticals and biologically active compounds. Additionally, 4-(3-Hydroxyphenyl)piperidine has potential applications in the development of new drugs for the treatment of neurological and psychiatric disorders. Its unique chemical structure and pharmacological properties make it a valuable tool in drug discovery and development efforts.

Upstream product

• 194669-45-9 4-(3-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 766-85-8 3-methoxy-1-iodobenzene 
• 1307314-95-9 4-(3-methoxy-phenyl)-piperidine trifluoroacetate 
• 1276045-26-1 4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 325808-20-6 4-(3-methoxyphenyl)piperidine hydrogen chloride salt 

Downstream Products

• 1026155-24-7 4-(3-hydroxyphenyl)-1-(3-pyridinecarbonyl)piperidine 
• 325808-21-7 1-(4-fluorobenzoyl)-4-(3-hydroxyphenyl)piperidine 
• 325808-26-2 4-(3-hydroxyphenyl)-1-[4-(trifluoromethyl)benzoyl]piperidine 
• 325808-34-2 4-(3-hydroxyphenyl)-1-(4-methylbenzoyl)piperidine 
• 325808-22-8 1-(4-chlorobenzoyl)-4-(3-hydroxyphenyl)piperidine 
• 325808-27-3 1-(2,4-difluorobenzoyl)-4-(3-hydroxyphenyl)piperidine 
• 325808-29-5 1-(3-fluorobenzoyl)-4-(3-hydroxyphenyl)piperidine 
• 325808-25-1 1-(4-bromobenzoyl)-4-(3-hydroxyphenyl)piperidine 
• 325808-23-9 1-(2-fluorobenzoyl)-4-(3-hydroxyphenyl)piperidine 
• 250732-81-1 N-hexyl-4-(3-hydroxyphenyl)piperidine 
• 1276045-12-5 cyclopropyl-[4-(3-hydroxy-phenyl)-piperidin-1-yl]-methanone 
• 1276045-10-3 cyclopropyl-[4-(3-ethoxy-phenyl)-piperidin-1-yl]-methanone 
• 1491161-27-3 3,3′-[1,1′-(6-(heptyloxy)-1,3,5-triazine-2,4-diyl)bis(piperidine-4,1-diyl)]diphenol 

Relevant articles and documents

Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl- cyclopropane carboxamide derivatives as novel melatonin receptor ligands

Two series of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT1 and MT2 receptors are reported. Compounds 11f and 18b (MT 1/MT2 agonist) have human microsomal intrinsic clearance comparable to ramelteon.

New strong fibrates with piperidine moiety

New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxy]-2-methylpropanoic acid (9