4-(3-Hydroxyphenyl)piperidine

Base Information

• Chemical Name: 4-(3-Hydroxyphenyl)piperidine
• CAS No.: 110878-71-2
• Molecular Formula: C11H15 N O
• Molecular Weight: 177.246
• Hs Code.: 2933399090
• European Community (EC) Number: 680-037-2
• DSSTox Substance ID: DTXSID20442024
• Wikidata: Q82259075
• ChEMBL ID: CHEMBL2021627
• Mol file: 110878-71-2.mol

Synonyms:4-(3-Hydroxyphenyl)piperidine;110878-71-2;3-(piperidin-4-yl)phenol;3-Piperidin-4-yl-phenol;Phenol, 3-(4-piperidinyl)-;3-Piperidin-4-ylphenol;3-(4-piperidyl)phenol;CHEMBL2011559;3-(4-Piperidinyl)phenol;HYDROXYPHENYL)PIPERID;SCHEMBL366769;CHEMBL2021627;DTXSID20442024;FINLIMGQGJZNRN-UHFFFAOYSA-N;BDBM50379814;MFCD02093474;3-(4-Piperidinyl)phenol, AldrichCPR;SB30674;AS-47409;CS-0269197;FT-0616588;H0965;F13613;EN300-1171491

Chemical Property of 4-(3-Hydroxyphenyl)piperidine

Chemical Property:

• Melting Point: 225°C
• Boiling Point: 320.9°Cat760mmHg
• PKA: 9.85±0.10(Predicted)
• Flash Point: 139.8°C
• PSA: 32.26000
• Density: 1.073g/cm³
• LogP: 2.18800
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

98% ^*data from raw suppliers

4-(3-Hydroxyphenyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C2=CC(=CC=C2)O

Technology Process of 4-(3-Hydroxyphenyl)piperidine

There total 8 articles about 4-(3-Hydroxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-(3-methoxyphenyl)piperidine hydrogen chloride salt (325808-20-6) → 4-(3-hydroxyphenyl)piperidine (110878-71-2)

Guidance literature:

With hydrogen bromide; for 2h; Heating;

DOI:10.1248/cpb.48.1978

Reference yield: 43.0%

→ 4-(3-hydroxyphenyl)piperidine (110878-71-2)

Guidance literature:

Reference yield: 15.0%

4-(3-methoxy-phenyl)-piperidine trifluoroacetate (1307314-95-9) → 4-(3-hydroxyphenyl)piperidine (110878-71-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.12.068

upstream raw materials:

4-(3-methoxyphenyl)piperidine hydrogen chloride salt

4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

4-(3-methoxy-phenyl)-piperidine trifluoroacetate

3-methoxy-1-iodobenzene

Downstream raw materials:

4-(3-hydroxyphenyl)-1-(3-pyridinecarbonyl)piperidine

4-(3-hydroxyphenyl)-1-(2,4,6-trifluorobenzoyl)piperidine

1-[3,5-di(tert-butyl)-4-hydroxybenzoyl]-4-(3-hydroxyphenyl)piperidine

1-(4-fluorobenzoyl)-4-(3-hydroxyphenyl)piperidine