110884-74-7

Usage

Uses

Used in Organic Synthesis:
(-)-(S)-p-nitrophenyl 1-phenylethyl carbonate is used as a reagent for the synthesis of chiral alcohols and amines, playing a crucial role in the production of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (-)-(S)-p-nitrophenyl 1-phenylethyl carbonate is used as a key intermediate in the synthesis of various drugs, leveraging its unique stereochemistry to produce enantiomerically pure molecules that are essential for the development of effective and safe medications.
Used in Chemical Research:
(-)-(S)-p-nitrophenyl 1-phenylethyl carbonate is utilized in chemical research as a versatile reagent for various chemical transformations, including the study of its p-nitrophenyl group, which contributes to its reactivity and applicability in different chemical processes.

Upstream product

• 1445-91-6 (S)-1-phenylethanol 
• 7693-46-1 4-Nitrophenyl chloroformate 

Downstream Products

• 924913-95-1 (2R*,4S*)-2-ethyl-6-methoxy-4-[(S)-1-phenylethoxycarbonylamino]-3,4-dihydro-2H-[1,5]naphthyridine-1-carboxylic acid ethyl ester 
• 188302-85-4 [(S)-1-Cyclohexyl-2,4-dioxo-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid (S)-1-phenyl-ethyl ester 

Relevant academic research and scientific papers

MCL1 INHIBITORS

The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

MCL-1 INHIBITORS

The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

Condensed Azepine Derivatives As Bromodomain Inhibitors

Benzodiazepine compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

CONDENSED AZEPINE DERIVATIVES AS BROMODOMAIN INHIBITORS

Benzodiazepine compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME

A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, and R8 are independently hydrogen; alkyl, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).

Enantioselectivity Effects in Hydrolytic Cleavage of Activated Substrates with α- and β-Cyclodextrins

The kinetics of hydrolytic cleavage of the enantiomers of p- and m-nitrophenyl (Np) phenylacatate esters of general structure PhCR1R2-CO2-Np where R1,R2=H, Me , H, OMe , or CF3, OMe , and of the carbonates PhCHMe-OCO2-p-Np (7) and n-C6H13-CHMe-OCO2-p-Np (8), have been measured in the presence of α- and β-cyclodextrins.The rates of intracomplex cleavage were found to be larger for the R- than for the S-enantiomers in almost all cases; the enantioselectivity factors range from unity to ca. 19 depending on the relative size of the pairs of substituents R1 and R2.The effects have been interpreted with the help of molecular models.