1109218-03-2Relevant articles and documents
Derivatives of tramadol for increased duration of effect
Shao, Liming,Abolin, Craig,Hewitt, Michael C.,Koch, Patrick,Varney, Mark
, p. 691 - 694 (2006)
Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. Analogs of tramadol with deuterium-for-hydrogen replacement at metabolically active sites were prepared and evaluated in vitro and in vivo.
SUBSTITUTED CYCLOHEXANOLS
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Page/Page column 32-33, (2009/02/11)
Disclosed herein are substituted cyclohexanol opioid receptor modulators and/or neurotransmitter reuptake modulators of Formula I or Formula II, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.