1109226-43-8Relevant articles and documents
Solvent-free palladium-catalyzed direct arylation of heteroaromatics with aryl bromides
Bensaid, Souhila,Doucet, Henri
experimental part, p. 1559 - 1567 (2012/10/08)
Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol%) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides. Copyright
Palladium-catalysed direct arylations of heteroaromatics using more eco-compatible solvents pentan-1-ol or 3-methylbutan-1-ol
Bensaid, Souhila,Laidaoui, Nouria,El Abed, Douniazad,Kacimi, Soufi,Doucet, Henri
experimental part, p. 1383 - 1387 (2011/03/22)
The palladium-catalysed direct coupling of aryl halides with heteroaromatics in greener solvents than DMF or DMAc, which are often employed for such couplings, would be a considerable advantage for both industrial application and sustainable development.