110927-71-4

Upstream product

• 7486-35-3 tri-n-butyl(vinyl)tin 
• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 1878-67-7 3-Bromophenylacetic acid 

Downstream Products

• 1365392-94-4 methyl 2-(3-(hydroxymethyl)phenyl)acetate 
• 1417556-94-5 (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-hydroxyethyl)phenyl)acetamido)-N-methyl-3-phenylpropanamide 
• 1417557-09-5 2-[3-(2-hydroxyethyl)phenyl] acetic acid 
• 89723-25-1 (3-ethyl-phenyl)-acetic acid 
• 494221-81-7 7-{(2R)-2-[(1E,3S)-3-hydroxy-4-(3-ethylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl}heptanoic acid 
• 1365391-79-2 ethyl 7-{(2R)-2-[(1E,3S)-3-hydroxy-4-(3-ethylphenyl)-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}heptanoate 
• 1357177-81-1 dimethyl [3-(3-ethylphenyl)-2-oxopropane]phosphonate 
• 1283119-95-8 C₁₂H₁₇NO₂ 
• 1365392-84-2 methyl (3-ethylphenyl)acetate 
• 494222-37-6 4-[(2-{(2R)-2-[(1E,3S)-3-hydroxy-4-(3-ethylphenyl)but-1-enyl]-5-oxopyrrolidin-1-yl}ethyl)sulfanyl]butanoic acid 
• 1365393-24-3 C₂₆H₃₉NO₄S 

Relevant academic research and scientific papers

Novel compounds that are inhibitors of YAP/TAZ-TEAD interaction and their use in the treatment of malignant mesothelioma

These compounds are useful as inhibitors of the YAP/TAZ-TEAD interaction.

COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.

ANTIVIRAL COMPOUNDS

The present invention relates to a compound of formula: (I) or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing a viral infection such as HIV using the same.

Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists

Analogs 8-aza-16-aryl prostaglandin E1 (PGE1) and 8-aza-5-thia-16-arylPGE1 were synthesized and evaluated with respect to their subtype receptor affinity and EP4 agonist activity for the purposes of identifying sub-type- selective EP