110931-72-1Relevant academic research and scientific papers
Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
Boyd, Helen F.,Fell, Stephen C.M.,Hickey, Deirdre M.B.,Ife, Robert J.,Leach, Colin A.,Macphee, Colin H.,Milliner, Kevin J.,Pinto, Ivan L.,Rawlings,Smith, Stephen A.,Stansfield, Ian G.,Stanway, Steven J.,Theobald, Colin J.,Whittaker, Caroline M.
, p. 51 - 55 (2007/10/03)
A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A2 with high potency in whole human plasma. 5-(Pyrazolylmethyl) derivative 16 and 5-(methoxypyrimidinylmethyl) derivative 27 demonstrated excellent pharmacodynamic profiles which correlated well with their pharmacokinetic effects.
Mono and double modified teicoplanin aglycon derivatives on the amino acid No. 7; Structure-activity relationship
Pavlov, Andrei Y.,Preobrazhenskaya, Maria N.,Malabarba, Adriano,Ciabatti, Romeo,Colombo, Luigi
, p. 73 - 81 (2007/10/03)
A series of 7d-aminomethylated derivatives (mono modified) and their amides (double modified) at the amino acid No. 7 of teicoplanin aglycon were prepared with the aim of obtaining activity against vancomycin-resistant VanA enterococci. Among mono modified compounds, the 7d-n-decylaminomethyl derivative was the most active against VanA enterococci (4 μg/ml). Amides of the latter with 3-dimethylamino-propylamine or methylamine were found to be up to four times more active against glycopeptide-susceptible Gram-positive bacteria, and up to four times less active against VanA enterococci than the starting compound.
A new type of chemical modification of glycopeptides antibiotics: Aminomethylated derivatives of eremomycin and their antibacterial activity
Pavlov, Andrei Y.,Lazhko, Eduard I.,Preobrazhenskaya, Maria N.
, p. 509 - 513 (2007/10/03)
A series of derivatives of eremomycin aminomethylated at the 7d position of the resorcinol ring of the amino acid No. 7 was prepared by interaction of eremomycin with formaldehyde and various primary and secondary amines and ammonia. The most active compo
Amine derivatives, processes for their production and their use
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, (2008/06/13)
Compounds of formula I STR1 wherein R1 represents a group of formula STR2 and R2 represents hydrogen or lower alkyl, or R1 and R2 together with the carbon atom to which they are attached represent a group of for
