110936-08-8

Upstream product

• 17451-21-7 4-(4-methoxyphenyl)-2-oxo-3-butenoic acid 
• 14425-64-0 4-methoxyphenethyl bromide 
• 22767-72-2 ethyl 3-(4-methoxyphenyl)propanoate 
• 18217-00-0 1-(2-Chloroethyl)-4-methoxybenzene 
• 88768-19-8 ethyl 4-(p-methoxyphenyl)-2-ketobutanoate 
• 184242-36-2 (4-methoxy-benzyl)-oxalacetic acid diethyl ester 

Downstream Products

• 110936-10-2 (E)-2-Methoxycarbonylamino-4-(4-methoxy-phenyl)-but-2-enoic acid 
• 110971-27-2 (2Z)-2-<(methoxycarbonyl)amino>-4-(4-methoxyphenyl)but-2-enoic acid 
• 364603-85-0 2-hydroxy-4-(4-methoxyphenyl)-2-(4-methylphenacyl)butanoic acid 
• 1327337-58-5 C₁₁H₁₄O₄ 
• 364603-89-4 6-(4-methoxy-phenyl)-4-[2-(4-methoxy-phenyl)-ethyl]-2H-pyridazin-3-one 
• 364603-88-3 4-[2-(4-methoxy-phenyl)-ethyl]-6-p-tolyl-2H-pyridazin-3-one 
• 364603-91-8 3-chloro-4-[2-(4-methoxy-phenyl)-ethyl]-6-p-tolyl-pyridazine 
• 364603-92-9 3-chloro-6-(4-methoxy-phenyl)-4-[2-(4-methoxy-phenyl)-ethyl]-pyridazine 
• 364603-90-7 3-chloro-4-[2-(4-methoxy-phenyl)-ethyl]-6-phenyl-pyridazine 
• 364603-87-2 4-[2-(4-methoxy-phenyl)-ethyl]-6-phenyl-2H-pyridazin-3-one 
• 364603-86-1 2-hydroxy-2-(4-methoxyphenyl)-4-(4-methylphenacyl)butanoic acid 
• 364603-84-9 2-hydroxy-4-(4-methoxyphenyl)-2-phenacylbutanoic acid 
• 106591-92-8 2-hydroxy-2-(4-methoxy-phenethyl)-4-oxo-valeric acid 

Relevant academic research and scientific papers

Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids

The Ru-catalyzed asymmetric hydrogenation of 2-oxo-4-arybutanoic acids to afford 2-hydroxy-4-arybutanoic acids was accomplished by employing SunPhos as chiral ligand and 1 M aq HBr as additive. The high enantioselectivities (88.4%-92.6% ee) and efficiency (TON=10,000, TOF=300 h-1) make this method efficient for the synthesis of an important intermediate, (R)-2-hydroxy-4-phenylbutanoic acid, for ACE inhibitors.

Practical Enantioselective Synthesis of a Homotyrosine Derivative and (R,R)-4-Propyl-9-hydroxynaphthoxazine, a Potent Dopamine Agonist

Two enantioselective routes were developed to prepare chiral amino acid derivative 4.The key step in the first route was catalytic hydrogenation of acrylate derivative 3 using chiral rhodium catalysts.In the second route the key step was acylation of 2-ch