364603-87-2Relevant academic research and scientific papers
Construction of Some Pyridazine Derivatives and their Annelated Ring Systems from Keto Acids
El Massry, Abdel Moneim,Rahman, Mohamed M. Abdel,El Sayed, Safaa,El Ashry, El Sayed H.
, p. 159 - 166 (2007/10/03)
2-Hydroxy-4-(4-methoxyphenyl)-2-(4-substituted phenacyl)butanoic acids 1 have been prepared from reaction of 4-methoxybenzylpyruvic acid with aryl methyl ketones. A new series of 2,3-dihydropyridazin-3-ones 2 were synthesized via condensation of 1 with hydrazine.The 1,2,4-triazolo[4,3-b]pyridazinones 4 and tetrazolo[1,5-b]pyridazines 6 were obtained from the 3-chloropyridazines 3 by treatment with semicarbazide and sodium azide, respectively. Attempted synthesis of 3-alloxypyridazines 7 by reacting 3 with sodium alloxide led instead to the N-allyl isomer 8 through Claisen rearrangement of 7. The structural assignments for the new compounds were based on their elemental analysis and spectroscopic data.
