111009-89-3

Upstream product

• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 147-85-3 L-proline 

Downstream Products

• 1258866-13-5 (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methylallyl)-decahydro-12-oxa-3a,6-diaza-cyclopentacyclododecene-4,7,13-trione 
• 1258866-18-0 (5R,8R,9S,11R,13aS)-5-benzyl-9-(tert-butyldimethylsilyloxy)-8-methyl-11-((S)-1-methyl-6-oxoheptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione 
• 1259035-47-6 (5R,8R,9S,11R,13aS)-5-benzyl-9-hydroxy-8-methyl-11-((S)-1-methyl-6-oxo-heptyl)-decahydro-12-oxa-3a,6-diazacyclopentacyclododecene-4,7,13-trione 

Relevant academic research and scientific papers

Expedient synthesis of a stereoisomer of acremolide B

A highly straightforward strategy for the synthesis of the acremolide class of lipodepsipeptides has been developed. Synthetic highlights include a cross-metathesis to couple the C1-C7 and the C8-C12 fragments, an esterification to introduce the dipeptide unit, a macrolactamization to build the macrolide core, and two stereoselective allylations/crotylations to control all four stereogenic centers of the C1-C12 polypropionate segment.