111042-90-1

Basic information

• Product Name: METHYL 3-AMINOTHIENO[3,2-B]PYRIDINE-2-CARBOXYLATE
• Synonyms: METHYL 3-AMINOTHIENO[3,2-B]PYRIDINE-2-CARBOXYLATE;Thieno[3,2-b]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI);Methyl 3-aMinothieno[3;Methyl 3-AMino-thieno[3,2-b]pyridin-2-carboxylate;Methyl 3-aMinothieno[3,2-...;3-AMino-thieno[3,2-b]pyridine-2-carboxylic acid Methyl ester
• CAS NO: 111042-90-1
• Molecular Formula: C₉H₈N₂O₂S
• Molecular Weight: 208.24
• Product Categories: AMINOACID;CHIRAL CHEMICALS
• Mol File: 111042-90-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 122 °C
• Boiling Point: 377.553 °C at 760 mmHg
• Flash Point: 182.138 °C
• Appearance: /
• Density: 1.422 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.7
• Storage Temp.: 2-8°C
• PKA: 4.05±0.40(Predicted)
• CAS DataBase Reference: METHYL 3-AMINOTHIENO[3,2-B]PYRIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-AMINOTHIENO[3,2-B]PYRIDINE-2-CARBOXYLATE(111042-90-1)
• EPA Substance Registry System: METHYL 3-AMINOTHIENO[3,2-B]PYRIDINE-2-CARBOXYLATE(111042-90-1)

Safety Data

• Hazardous Substances Data: 111042-90-1(Hazardous Substances Data)

Usage

General Description

METHYL 3-AMINOTHIENO[3,2-B]PYRIDINE-2-CARBOXYLATE is a chemical compound with the molecular formula C11H9N3O2S. It is a synthetic organic compound that contains a thienopyridine ring with an aminocarbonyl group. METHYL 3-AMINOTHIENO[3,2-B]PYRIDINE-2-CARBOXYLATE is commonly used as a building block in the synthesis of pharmaceutical drugs and agrochemicals. It has potential applications in medicinal chemistry and drug development due to its structural versatility and potential biological activities. The compound may also be used as a reagent in various chemical reactions and as a precursor in the synthesis of other functionalized heterocycles. Overall, METHYL 3-AMINOTHIENO[3,2-B]PYRIDINE-2-CARBOXYLATE has important industrial and research applications in the field of organic chemistry.

InChI:InChI=1/C9H8N2O2S/c1-13-9(12)8-6(10)7-5(14-8)3-2-4-11-7/h2-4H,10H2,1H3

Upstream product

• 38180-46-0 3-chloro-2-cyanopyridine 
• 2365-48-2 Methyl thioglycolate 
• 97509-75-6 3-fluoropicolinonitrile 
• 1851-22-5 3-chloropyridine-N-oxide 
• 626-60-8 3-Chloropyridine 

Downstream Products

• 1206907-39-2 methyl 3-(2-nitrophenylamino)thieno[3,2-b]pyridine-2-carboxylate 
• 1206907-40-5 methyl 3-(4-nitrophenylamino)thieno[3,2-b]pyridine-2-carboxylate 
• 94191-19-2 2-hydroxymethylthieno<3,2-b>pyridine 
• 478149-02-9 methyl thieno[3,2-b]pyridine-2-carboxylate 
• 1206907-42-7 methyl 3-(4-aminophenylamino)thieno[3,2-b]pyridine-2-carboxylate 
• 1206907-41-6 methyl 3-(2-aminophenylamino)thieno[3,2-b]pyridine-2-carboxylatete 

Related news

New 1,3-diarylureas linked by CC Suzuki coupling to the methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate moiety: Synthesis and fluorescence studies in solution and in lipid membranes08/22/2019

New six fluorescent 1,3-diarylureas linked by CC Suzuki coupling to the 6-position of the methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate moiety were prepared by reaction of the amino groups on the ortho or meta positions relative to the CC bond of the Suzuki coupling products, with different ...detailed

Relevant articles and documents

First metal-free synthesis of tetracyclic pyrido and pyrazino thienopyrimidinone molecules

We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2,3:4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

Synthesis of new thieno[3,2-b]pyridine derivatives by palladium-catalyzed couplings and intramolecular cyclizations

Two methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates were prepared from 3-fluoro or 3-nitropicolinonitriles and methyl thioglycolate in DMF/KOH(aq). From the unsubstituted precursor in the pyridine ring, di(hetero)arylamines were obtained by C-N Buchwald-Hartwig coupling with bromonitrobenzenes and with 2-bromopyridine. In the latter case a tetracyclic compound was formed by intramolecular cyclization. Using a brominated derivative in the pyridine ring as a coupling component, it was possible to synthesize C-C (Suzuki and Sonogashira) and C-N (Buchwald-Hartwig) coupling products and a tetracyclic compound obtained by bifunctionalization of the thienopyridine system.