111055-87-9

Basic information

• Product Name: (E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester
• Synonyms: (E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester
• CAS NO: 111055-87-9
• Molecular Formula: C₁₁H₁₀F₂O₂
• Molecular Weight: 212.19
• Mol File: 111055-87-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester(111055-87-9)
• EPA Substance Registry System: (E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester(111055-87-9)

Safety Data

• Hazardous Substances Data: 111055-87-9(Hazardous Substances Data)

Usage

General Description

(E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester is a chemical compound with the formula C11H9F2O2. It is an ethyl ester derivative of (E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, which is a synthetic intermediate used in the production of pharmaceuticals and agrochemicals. (E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester is a fluorinated derivative, meaning it contains fluorine atoms, which can impart unique properties to the molecule, such as increased stability and bioavailability. It is often used in the research and development of new drugs and chemical products, and its properties make it an important building block in various chemical synthesis processes.

Upstream product

• 401-58-1 ethyl 2-fluoro-2-iodoacetate 
• 459-57-4 4-fluorobenzaldehyde 
• 459-72-3 ethyl 2-fluoroacetate 
• 401-55-8 ethyl bromofluoroacetate 
• 71013-80-4 (Z)-1-(4-fluorophenyl)-N-phenylmethanimine oxide 

Downstream Products

• 94977-49-8 α,p-difluoro-trans-cinnamic acid 

Relevant articles and documents

Stereoselective synthesis of fluoroalkenoates and fluorinated isoxazolidinones: N-substituents governing the dual reactivity of nitrones

α-Fluoroalkenoates and 4-fluoro-5-isoxazolidinones are of vast interest due to their potential biological applications. We now demonstrate the syntheses of (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones by the reactions between nitrones and α-fluoro-α-bromoacetate. By altering N-substituents in nitrones, (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones can be achieved, respectively, with high chemo- and stereoselectivities. Experimental and computational studies have been conducted to elucidate the reaction mechanisms. Linear free energy relationship studies further revealed that the N-substituent effects are primarily of electronic origin. Copyright

Preparation et spectres de RMN, H, F et C-13 d'esters α-fluoro-cinnamiques para- et meta-substitues

In this publication we present H, F and C-13 NMR spectra of a series of para (11 examples) and meta (7 examples) substituted α-fluoro-Z-cinnamic esters and their corresponding acids.We also discuss the characteristics and scope of the various preparation