111055-87-9

Usage

Uses

Used in Pharmaceutical Industry:
(E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester is used as a synthetic intermediate for the development of new pharmaceuticals. Its fluorinated nature and unique properties contribute to the creation of more stable and bioavailable drug candidates.
Used in Agrochemical Industry:
In the agrochemical industry, (E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester is used as a building block for the synthesis of various agrochemicals. Its properties can enhance the effectiveness and stability of these products, leading to improved performance in agricultural applications.
Used in Chemical Research and Development:
(E)-2-Fluoro-3-(4-fluorophenyl)-propenoic acid, ethyl ester is utilized in the research and development of new chemical products. Its unique properties make it a valuable compound for exploring novel chemical reactions and syntheses, potentially leading to the discovery of innovative materials and applications.

Upstream product

• 401-55-8 ethyl bromofluoroacetate 
• 71013-80-4 (Z)-1-(4-fluorophenyl)-N-phenylmethanimine oxide 
• 459-72-3 ethyl 2-fluoroacetate 
• 459-57-4 4-fluorobenzaldehyde 
• 401-58-1 ethyl 2-fluoro-2-iodoacetate 

Downstream Products

• 94977-49-8 α,p-difluoro-trans-cinnamic acid 

Relevant academic research and scientific papers

Stereoselective synthesis of fluoroalkenoates and fluorinated isoxazolidinones: N-substituents governing the dual reactivity of nitrones

α-Fluoroalkenoates and 4-fluoro-5-isoxazolidinones are of vast interest due to their potential biological applications. We now demonstrate the syntheses of (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones by the reactions between nitrones and α-fluoro-α-bromoacetate. By altering N-substituents in nitrones, (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones can be achieved, respectively, with high chemo- and stereoselectivities. Experimental and computational studies have been conducted to elucidate the reaction mechanisms. Linear free energy relationship studies further revealed that the N-substituent effects are primarily of electronic origin. Copyright

A convenient palladium-catalyzed synthesis of α-fluoro-α,β-unsaturated esters

During the treatment of ethyl α-fluoro-α-iodoacetate with aldehydes in the presence of tri-n-butylarsine and a catalytic amount (10 molpercent) of Pd(PPh3)4, the aldehydes were eventually completely consumed and α-fluoro-α,β-unsaturated esters were obtained in 52-90percent yield.

Preparation et spectres de RMN, H, F et C-13 d'esters α-fluoro-cinnamiques para- et meta-substitues

In this publication we present H, F and C-13 NMR spectra of a series of para (11 examples) and meta (7 examples) substituted α-fluoro-Z-cinnamic esters and their corresponding acids.We also discuss the characteristics and scope of the various preparation

Fluorine-19 Nuclear Magnetic Resonance Study of the Inclusion of Fluoro- and Difluoro-trans-cinnamates by α-Cyclodextrin

19F n.m.r. studies of the inclusion of o-, m-, p- and α-fluoro-trans-cinnamates and o, p- and α,p-difluoro-trans-cinnamates by α-cyclodextrin (αCD) have shown that two inclusion equilibria S + αCD S*αCD (K1), S*αCD + αCD S*(αCD)2 (Ksub