1111071-92-1Relevant articles and documents
PhSeZnCl in the synthesis of steroidal β-Hydroxy- phenylselenides having antibacterial activity
Jastrzebska, Izabella,Mellea, Stefano,Salerno, Valerio,Grzes, Pawel Adam,Siergiejczyk, Leszek,Niemirowicz-Laskowska, Katarzyna,Bucki, Robert,Monti, Bonifacio,Santi, Claudio
, (2019)
We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation.